Mur ligase F as a new target for the flavonoids quercitrin, myricetin, and (-)-epicatechin.


Journal

Journal of computer-aided molecular design
ISSN: 1573-4951
Titre abrégé: J Comput Aided Mol Des
Pays: Netherlands
ID NLM: 8710425

Informations de publication

Date de publication:
12 2023
Historique:
received: 12 07 2023
accepted: 14 09 2023
medline: 2 11 2023
pubmed: 5 10 2023
entrez: 5 10 2023
Statut: ppublish

Résumé

MurC, D, E, and F are ATP-dependent ligases involved in the stepwise assembly of the tetrapeptide stem of forming peptidoglycan. As highly conserved targets found exclusively in bacterial cells, they are of significant interest for antibacterial drug discovery. In this study, we employed a computer-aided molecular design approach to identify potential inhibitors of MurF. A biochemical inhibition assay was conducted, screening twenty-four flavonoids and related compounds against MurC-F, resulting in the identification of quercitrin, myricetin, and (-)-epicatechin as MurF inhibitors with IC

Identifiants

pubmed: 37796382
doi: 10.1007/s10822-023-00535-z
pii: 10.1007/s10822-023-00535-z
pmc: PMC10618370
doi:

Substances chimiques

Ligases EC 6.-
myricetin 76XC01FTOJ
Catechin 8R1V1STN48
quercitrin 2Y8906LC5P
Peptidoglycan 0
Flavonoids 0
Adenosine Triphosphate 8L70Q75FXE
Peptide Synthases EC 6.3.2.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

721-733

Informations de copyright

© 2023. The Author(s).

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Auteurs

Martina Hrast Rambaher (MH)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000, Ljubljana, Slovenia.

Irena Zdovc (I)

Veterinary Faculty, Institute of Microbiology and Parasitology, University of Ljubljana, Gerbičeva ul. 60, Ljubljana, Slovenia.

Nina Kočevar Glavač (NK)

Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000, Ljubljana, Slovenia.

Stanislav Gobec (S)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000, Ljubljana, Slovenia. stanislav.gobec@ffa.uni-lj.si.

Rok Frlan (R)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000, Ljubljana, Slovenia. rok.frlan@ffa.uni-lj.si.

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