Superiority of the Triple-Acting 5-HT

Rats Animals Serotonin / adverse effects Cryoelectron Microscopy Receptors, Serotonin Serotonin Antagonists / pharmacology Alzheimer Disease / drug therapy Monoamine Oxidase Cognition Monoamine Oxidase Inhibitors / pharmacology

Journal

Journal of medicinal chemistry

ISSN: 1520-4804

Titre abrégé: J Med Chem

Pays: United States

ID NLM: 9716531

Informations de publication

Date de publication:
09 11 2023

Historique:

medline: 10 11 2023

pubmed: 5 10 2023

entrez: 5 10 2023

Statut: ppublish

Résumé

The multifactorial origin and neurochemistry of Alzheimer's disease (AD) call for the development of multitarget treatment strategies. We report a first-in-class triple acting compound that targets serotonin type 6 and 3 receptors (5-HT-Rs) and monoamine oxidase type B (MAO-B) as an approach for treating AD. The key structural features required for MAO-B inhibition and 5-HT

Identifiants

DOI: 10.1021/acs.jmedchem.3c01482 PMID: 37797083 PMC: PMC10641814

pubmed: 37797083

doi: 10.1021/acs.jmedchem.3c01482

pmc: PMC10641814

doi:

Substances chimiques

Serotonin 333DO1RDJY

3-benzenesulfonyl-8-piperazin-1-ylquinoline 0

Receptors, Serotonin 0

Serotonin Antagonists 0

Monoamine Oxidase EC 1.4.3.4

Monoamine Oxidase Inhibitors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

14928-14947

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