High-throughput electron tomography identifies centriole over-elongation as an early event in plasma cell disorders.


Journal

Leukemia
ISSN: 1476-5551
Titre abrégé: Leukemia
Pays: England
ID NLM: 8704895

Informations de publication

Date de publication:
Dec 2023
Historique:
received: 02 08 2023
accepted: 29 09 2023
revised: 14 09 2023
medline: 29 11 2023
pubmed: 12 10 2023
entrez: 11 10 2023
Statut: ppublish

Résumé

Plasma cell disorders are clonal outgrowths of pre-malignant or malignant plasma cells, characterized by extensive chromosomal aberrations. Centrosome abnormalities are a major driver of chromosomal instability in cancer but their origin, incidence, and composition in primary tumor cells is poorly understood. Using cutting-edge, semi-automated high-throughput electron tomography, we characterized at nanoscale 1386 centrioles in CD138

Identifiants

pubmed: 37821581
doi: 10.1038/s41375-023-02056-y
pii: 10.1038/s41375-023-02056-y
pmc: PMC10681902
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2468-2478

Subventions

Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : KR 1981/4-1
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : HE 8472/1-1
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : SCHO 1364/2-1

Informations de copyright

© 2023. The Author(s).

Références

Nat Genet. 2012 May 06;44(6):642-50
pubmed: 22561516
Nature. 2009 Jul 9;460(7252):278-82
pubmed: 19506557
Science. 2015 May 22;348(6237):880-6
pubmed: 25999502
Nat Commun. 2019 Aug 23;10(1):3835
pubmed: 31444325
PLoS Comput Biol. 2021 May 12;17(5):e1008765
pubmed: 33979341
Nat Rev Mol Cell Biol. 2007 Jun;8(6):451-63
pubmed: 17505520
Immunity. 2015 Jul 21;43(1):132-45
pubmed: 26187412
Open Biol. 2017 Jun;7(6):
pubmed: 28659385
Nature. 2019 Jan;565(7739):312-317
pubmed: 30602793
Nature. 2021 Sep;597(7876):381-386
pubmed: 34433962
N Engl J Med. 2014 Dec 25;371(26):2477-87
pubmed: 25426838
Blood. 2008 Feb 1;111(3):1603-9
pubmed: 18006703
N Engl J Med. 2006 Mar 30;354(13):1362-9
pubmed: 16571879
Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6321-30
pubmed: 26578792
Nature. 2019 Oct;574(7779):532-537
pubmed: 31645730
Nat Commun. 2020 Apr 21;11(1):1917
pubmed: 32317634
STAR Protoc. 2023 Jun 22;4(3):102373
pubmed: 37354457
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Science. 2018 Nov 23;362(6417):911-917
pubmed: 30337457
Leukemia. 2003 Nov;17(11):2207-13
pubmed: 14523473
Nat Rev Cancer. 2015 Nov;15(11):639-52
pubmed: 26493645
Curr Opin Struct Biol. 2021 Feb;66:89-95
pubmed: 33220554
Nat Med. 2021 Nov;27(11):1921-1927
pubmed: 34663986
Nat Methods. 2023 Apr;20(4):475-476
pubmed: 36765247
Science. 2020 Oct 2;370(6512):82-89
pubmed: 33004515
Nat Commun. 2018 Sep 26;9(1):3938
pubmed: 30258116
Open Biol. 2021 Feb;11(2):200399
pubmed: 33561384
Science. 2019 Nov 1;366(6465):
pubmed: 31672865
Cell Rep Methods. 2022 Nov 01;2(11):100322
pubmed: 36452870
Cancer Res. 2016 Nov 15;76(22):6690-6700
pubmed: 27634760
J Clin Invest. 2005 Mar;115(3):755-64
pubmed: 15711642
Nature. 2020 Jan;577(7789):260-265
pubmed: 31853061
JCI Insight. 2017 Oct 5;2(19):
pubmed: 28978808
Nature. 2020 Aug;584(7819):136-141
pubmed: 32581363
J Cell Biol. 2020 Jun 1;219(6):
pubmed: 32271878
Curr Biol. 2009 Jun 23;19(12):1012-8
pubmed: 19481460
Nature. 2020 Feb;578(7794):266-272
pubmed: 31996850
J Cell Biol. 2022 Dec 5;221(12):
pubmed: 36315013
J Cell Biol. 2013 Jul 22;202(2):211-9
pubmed: 23857771
Nat Commun. 2018 Mar 28;9(1):1258
pubmed: 29593297
Blood. 2006 May 1;107(9):3669-75
pubmed: 16373658
Curr Biol. 2013 Jul 22;23(14):1360-6
pubmed: 23810536
Haematologica. 2021 Oct 01;106(10):2754-2758
pubmed: 34092058
Cancer Cell. 2020 Dec 14;38(6):818-828.e5
pubmed: 33096021
Nat Genet. 2012 May 06;44(6):651-8
pubmed: 22561519
Science. 2019 Jun 07;364(6444):
pubmed: 31171663
Nature. 2018 Jul;559(7714):350-355
pubmed: 29995854
Nat Commun. 2015 Jul 22;6:7539
pubmed: 26198393
N Engl J Med. 2014 Dec 25;371(26):2488-98
pubmed: 25426837
J Cell Biol. 2018 Jul 2;217(7):2353-2363
pubmed: 29739803
Cell Rep. 2017 Aug 22;20(8):1906-1920
pubmed: 28834753
Nat Rev Clin Oncol. 2017 Feb;14(2):100-113
pubmed: 27531699
N Engl J Med. 2015 Jul 2;373(1):35-47
pubmed: 26132940
Nature. 2018 Jul;559(7714):400-404
pubmed: 29988082
Nature. 2021 Sep;597(7876):398-403
pubmed: 34433965
Nat Med. 2018 Jul;24(7):1015-1023
pubmed: 29988143
Nat Rev Mol Cell Biol. 2018 May;19(5):297-312
pubmed: 29363672
Nat Commun. 2022 Jan 10;13(1):151
pubmed: 35013207
Nature. 2020 Apr;580(7805):640-646
pubmed: 32350471
Dev Cell. 2017 Feb 6;40(3):313-322.e5
pubmed: 28132847

Auteurs

Sebastian Köhrer (S)

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.

Tobias Dittrich (T)

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Amyloidosis Center, University of Heidelberg, Heidelberg, Germany.

Martin Schorb (M)

Electron Microscopy Core Facility, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.

Niels Weinhold (N)

Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.

Isabella Haberbosch (I)

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.

Mandy Börmel (M)

Electron Microscopy Core Facility, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.

Gabor Pajor (G)

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Department of Pathology, University of Pécs Medical School and Clinic, Pécs, Hungary.

Hartmut Goldschmidt (H)

Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Department of Internal Medicine V, GMMG-Studygroup at University of Heidelberg, Heidelberg, Germany.

Carsten Müller-Tidow (C)

Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
National Center for Tumor Diseases (NCT), University of Heidelberg, Heidelberg, Germany.

Marc S Raab (MS)

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.

Lukas John (L)

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.

Anja Seckinger (A)

Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.

Alexander Brobeil (A)

Institute of Pathology, University of Heidelberg, Heidelberg, Germany.

Peter Dreger (P)

Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.

Tamás Tornóczky (T)

Department of Pathology, University of Pécs Medical School and Clinic, Pécs, Hungary.

László Pajor (L)

Department of Pathology, University of Pécs Medical School and Clinic, Pécs, Hungary.

Ute Hegenbart (U)

Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Amyloidosis Center, University of Heidelberg, Heidelberg, Germany.

Stefan O Schönland (SO)

Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Amyloidosis Center, University of Heidelberg, Heidelberg, Germany.

Yannick Schwab (Y)

Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. yannick.schwab@embl.de.
Electron Microscopy Core Facility, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. yannick.schwab@embl.de.

Alwin Krämer (A)

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany. a.kraemer@dkfz.de.
Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany. a.kraemer@dkfz.de.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH