Comparative transcriptomics reveals human-specific cortical features.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
13 10 2023
13 10 2023
Historique:
medline:
1
11
2023
pubmed:
12
10
2023
entrez:
12
10
2023
Statut:
ppublish
Résumé
The cognitive abilities of humans are distinctive among primates, but their molecular and cellular substrates are poorly understood. We used comparative single-nucleus transcriptomics to analyze samples of the middle temporal gyrus (MTG) from adult humans, chimpanzees, gorillas, rhesus macaques, and common marmosets to understand human-specific features of the neocortex. Human, chimpanzee, and gorilla MTG showed highly similar cell-type composition and laminar organization as well as a large shift in proportions of deep-layer intratelencephalic-projecting neurons compared with macaque and marmoset MTG. Microglia, astrocytes, and oligodendrocytes had more-divergent expression across species compared with neurons or oligodendrocyte precursor cells, and neuronal expression diverged more rapidly on the human lineage. Only a few hundred genes showed human-specific patterning, suggesting that relatively few cellular and molecular changes distinctively define adult human cortical structure.
Identifiants
pubmed: 37824638
doi: 10.1126/science.ade9516
pmc: PMC10659116
mid: NIHMS1941387
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eade9516Subventions
Organisme : NINDS NIH HHS
ID : R24 NS092988
Pays : United States
Organisme : NIMH NIH HHS
ID : U19 MH114821
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG009318
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH114812
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD105351
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH113005
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH114819
Pays : United States
Organisme : NIMH NIH HHS
ID : U19 MH114830
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG011641
Pays : United States
Organisme : NIMH NIH HHS
ID : F32 MH114501
Pays : United States
Organisme : NLM NIH HHS
ID : R01 LM012736
Pays : United States
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