Synthesis and biological evaluation of novel 3-(5-substituted-1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with a dual affinity for serotonin 5-HT

Humans Serotonin Plasma Membrane Transport Proteins / metabolism Serotonin Receptor, Serotonin, 5-HT1A / metabolism Indoles / chemistry Serotonin Receptor Agonists / pharmacology Structure-Activity Relationship
5-HT(1A) agonists 5-HT(1A)/SERT dual activity Antidepressants D(2) receptor ligands Multitarget directed ligand Serotonin reuptake inhibitors

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
12 2023
Historique:
received: 17 03 2023
revised: 20 09 2023
accepted: 29 09 2023
medline: 3 11 2023
pubmed: 13 10 2023
entrez: 12 10 2023
Statut: ppublish

Résumé

The serotonin 1A (5-HT

Identifiants

DOI: 10.1016/j.bioorg.2023.106903 PMID: 37827015
pubmed: 37827015
pii: S0045-2068(23)00564-3
doi: 10.1016/j.bioorg.2023.106903
pii:
doi:

Substances chimiques

Serotonin Plasma Membrane Transport Proteins 0
Serotonin 333DO1RDJY
pyrrolidine-2,5-dione 0
Receptor, Serotonin, 5-HT1A 112692-38-3
Indoles 0
Serotonin Receptor Agonists 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

106903

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Martyna Z Wróbel (MZ)

Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warszawa, Poland. Electronic address: martyna.wrobel@wum.edu.pl.

Andrzej Chodkowski (A)

Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warszawa, Poland.

Maciej Dawidowski (M)

Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warszawa, Poland.

Agata Siwek (A)

Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland.

Katarzyna Stachowicz (K)

Department of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343 Kraków, Poland.

Bernadeta Szewczyk (B)

Department of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343 Kraków, Poland.

Gabriel Nowak (G)

Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland; Department of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343 Kraków, Poland.

Grzegorz Satała (G)

Department of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343 Kraków, Poland.

Andrzej J Bojarski (AJ)

Department of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343 Kraków, Poland.

Jadwiga Turło (J)

Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warszawa, Poland.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthesis and biological evaluation of novel...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs de la sérotonine › Synthesis and biological evaluation of novel...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Sérotonine › Synthesis and biological evaluation of novel...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs sérotoninergiques › Récepteurs de la sérotonine de type 5-HT1 › Récepteur de la sérotonine de type 5-HT1A › Synthesis and biological evaluation of novel...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Synthesis and biological evaluation of novel...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents sérotoninergiques › Agonistes des récepteurs de la sérotonine › Synthesis and biological evaluation of novel...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Synthesis and biological evaluation of novel...