Revolutions in Lipid Isomer Resolution: Application of Ultrahigh-Resolution Ion Mobility to Reveal Lipid Diversity.

Isomerism Mass Spectrometry / methods Phosphatidylcholines / analysis Chromatography, Liquid Carbon

Journal

Analytical chemistry
ISSN: 1520-6882
Titre abrégé: Anal Chem
Pays: United States
ID NLM: 0370536

Informations de publication

Date de publication:
31 10 2023
Historique:
medline: 2 11 2023
pubmed: 17 10 2023
entrez: 17 10 2023
Statut: ppublish

Résumé

Many families of lipid isomers remain unresolved by contemporary liquid chromatography-mass spectrometry approaches, leading to a significant underestimation of the structural diversity within the lipidome. While ion mobility coupled to mass spectrometry has provided an additional dimension of lipid isomer resolution, some isomers require a resolving power beyond the capabilities of conventional platforms. Here, we present the application of high-resolution traveling-wave ion mobility for the separation of lipid isomers that differ in (i) the location of a single carbon-carbon double bond, (ii) the stereochemistry of the double bond (

Identifiants

DOI: 10.1021/acs.analchem.3c02658 PMID: 37847864
pubmed: 37847864
doi: 10.1021/acs.analchem.3c02658
doi:

Substances chimiques

Phosphatidylcholines 0
Carbon 7440-44-0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

15917-15923

Auteurs

Berwyck L J Poad (BLJ)

Central Analytical Research Facility, Queensland University of Technology, Brisbane 4001, Australia.
School of Chemistry and Physics, Queensland University of Technology, Brisbane 4000, Australia.
Centre for Materials Science, Queensland University of Technology, Brisbane 4000, Australia.
ORCID: 0000-0002-0420-6116

Lachlan J Jekimovs (LJ)

School of Chemistry and Physics, Queensland University of Technology, Brisbane 4000, Australia.

Reuben S E Young (RSE)

School of Chemistry and Physics, Queensland University of Technology, Brisbane 4000, Australia.
ORCID: 0000-0003-0620-3362

Puttandon Wongsomboon (P)

School of Chemistry and Physics, Queensland University of Technology, Brisbane 4000, Australia.

David L Marshall (DL)

Central Analytical Research Facility, Queensland University of Technology, Brisbane 4001, Australia.
Centre for Materials Science, Queensland University of Technology, Brisbane 4000, Australia.
ORCID: 0000-0002-1711-2338

Felicia K M Hansen (FKM)

School of Chemistry and Physics, Queensland University of Technology, Brisbane 4000, Australia.

Therese Fulloon (T)

School of Chemistry and Physics, Queensland University of Technology, Brisbane 4000, Australia.
Centre for Materials Science, Queensland University of Technology, Brisbane 4000, Australia.

Michael C Pfrunder (MC)

School of Chemistry and Physics, Queensland University of Technology, Brisbane 4000, Australia.
Centre for Materials Science, Queensland University of Technology, Brisbane 4000, Australia.
ORCID: 0000-0002-2270-7141

Tyren Dodgen (T)

Waters Australia,Rydalmere 2116, Australia.

Mark Ritchie (M)

Waters Pacific Pte. Ltd., 117528Singapore.

Stephen C C Wong (SCC)

Waters Pacific Pte. Ltd., 117528Singapore.

Stephen J Blanksby (SJ)

Central Analytical Research Facility, Queensland University of Technology, Brisbane 4001, Australia.
School of Chemistry and Physics, Queensland University of Technology, Brisbane 4000, Australia.
Centre for Materials Science, Queensland University of Technology, Brisbane 4000, Australia.
ORCID: 0000-0002-8560-756X

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Revolutions in Lipid Isomer Resolution:...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Revolutions in Lipid Isomer Resolution:...
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Glycérophospholipides › Phosphatidylcholines › Revolutions in Lipid Isomer Resolution:...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Revolutions in Lipid Isomer Resolution:...
questionsmedicales.fr › Produits chimiques inorganiques › Éléments › Carbone › Revolutions in Lipid Isomer Resolution:...