A mathematical model of cell movement and clustering due to chemotaxis.
Cell clustering
Cell migration
Chemotaxis
Mathematical modelling
Journal
Journal of theoretical biology
ISSN: 1095-8541
Titre abrégé: J Theor Biol
Pays: England
ID NLM: 0376342
Informations de publication
Date de publication:
07 Nov 2023
07 Nov 2023
Historique:
received:
24
10
2022
revised:
10
08
2023
accepted:
12
10
2023
medline:
20
11
2023
pubmed:
19
10
2023
entrez:
18
10
2023
Statut:
ppublish
Résumé
This paper presents a numerical method for modelling cell migration and aggregation due to chemotaxis where the cell is attracted towards the direction in which the concentration of a chemical signal is increasing. In the model presented here, each cell is represented by a system of springs connected together at node points on the cell's membrane and on the boundary of the cell's nucleus. The nodes located on a cell's membrane are subject to a force which is proportional to the gradient of the concentration of the chemical signal which mimics the behaviour of the chemical receptors in the cell's membrane. In particular, the model developed here will consider what happens when two (or more) cells collide and how their membranes connect to each other to form clusters of cells. The methods described in this paper will be illustrated with a number of typical examples simulating cells moving in response to a chemical signal and how they combine to form clusters.
Identifiants
pubmed: 37852358
pii: S0022-5193(23)00243-6
doi: 10.1016/j.jtbi.2023.111646
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111646Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.