Non-capsulated
Neisseria meningitides
eculizumab
paroxysmal nocturnal hemoglobinuria
proximal complement inhibitors
ravulizumab
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
29
07
2023
accepted:
30
08
2023
medline:
23
10
2023
pubmed:
19
10
2023
entrez:
19
10
2023
Statut:
epublish
Résumé
Paroxysmal nocturnal haemoglobinuria (PNH) is a rare acquired haematopoietic stem cell disease characterized by complement-mediated intravascular hemolysis, thrombosis, and bone marrow failure. Eculizumab and ravulizumab are anti-C5 monoclonal antibodies that reduce hemolysis, anaemia and thrombotic risk, but are associated with increased risk of infection with encapsulated bacteria, including
Identifiants
pubmed: 37854608
doi: 10.3389/fimmu.2023.1269325
pmc: PMC10580757
doi:
Substances chimiques
ravulizumab
C3VX249T6L
Complement Inactivating Agents
0
Types de publication
Review
Case Reports
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1269325Informations de copyright
Copyright © 2023 Galli, Pettine, Panigada, Daprai, Suriano, Grancini, Barcellini and Fattizzo.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
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