The rice peroxisomal receptor PEX5 negatively regulates resistance to rice blast fungus Magnaporthe oryzae.

Magnaporthe / metabolism Ascomycota / metabolism Ubiquitin-Protein Ligases / metabolism Aldehyde Dehydrogenase / genetics Plant Diseases Disease Resistance Plant Proteins / genetics Gene Expression Regulation, Plant
APIP6 CP: Plants E3 ubiquitin ligase Magnaporthe oryzae OsALDH2B1 OsAOS2 OsPEX5 aldehyde dehydrogenase peroxisome receptor protein rice

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
31 10 2023
Historique:
received: 21 07 2022
revised: 22 08 2023
accepted: 06 10 2023
medline: 6 11 2023
pubmed: 20 10 2023
entrez: 20 10 2023
Statut: ppublish

Résumé

The receptor protein PEX5, an important component of peroxisomes, regulates growth, development, and immunity in yeast and mammals. PEX5 also influences growth and development in plants, but whether it participates in plant immunity has remained unclear. Here, we report that knockdown of OsPEX5 enhances resistance to the rice blast fungus Magnaporthe oryzae. We demonstrate that OsPEX5 interacts with the E3 ubiquitin ligase APIP6, a positive regulator of plant immunity. APIP6 ubiquitinates OsPEX5 in vitro and promotes its degradation in vivo via the 26S proteasome pathway. In addition, OsPEX5 interacts with the aldehyde dehydrogenase OsALDH2B1, which functions in growth-defense trade-offs in rice. OsPEX5 stabilizes OsALDH2B1 to enhance its repression of the defense-related gene OsAOS2. Our study thus uncovers a previously unrecognized hierarchical regulatory mechanism in which an E3 ubiquitin ligase targets a peroxisome receptor protein that negatively regulates immunity in rice by stabilizing an aldehyde dehydrogenase that suppresses defense gene expression.

Identifiants

DOI: 10.1016/j.celrep.2023.113315 PMID: 37862164
pubmed: 37862164
pii: S2211-1247(23)01327-X
doi: 10.1016/j.celrep.2023.113315
pii:
doi:

Substances chimiques

Ubiquitin-Protein Ligases EC 2.3.2.27
Aldehyde Dehydrogenase EC 1.2.1.3
Plant Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

113315

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no conflicts of interest.

Auteurs

Xiaoman You (X)

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Shanshan Zhu (S)

National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agriculture Sciences, Beijing 100081, China.

Haowen Sheng (H)

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China; College of Agronomy, Hunan Agricultural University, Changsha, China.

Zheng Liu (Z)

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Dan Wang (D)

College of Agronomy, Hunan Agricultural University, Changsha, China.

Min Wang (M)

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Xiao Xu (X)

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Feng He (F)

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Hong Fang (H)

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Fan Zhang (F)

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Debao Wang (D)

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Zeyun Hao (Z)

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Ruyi Wang (R)

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Yinghui Xiao (Y)

College of Agronomy, Hunan Agricultural University, Changsha, China.

Jianmin Wan (J)

National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agriculture Sciences, Beijing 100081, China.

Guo-Liang Wang (GL)

Department of Plant Pathology, The Ohio State University, Columbus, OH 43210, USA.

Yuese Ning (Y)

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address: ningyuese@caas.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Champignons › Ascomycota › Magnaporthe › The rice peroxisomal receptor PEX5 negatively...
questionsmedicales.fr › Eucaryotes › Champignons › Ascomycota › The rice peroxisomal receptor PEX5 negatively...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Ubiquitin-protein ligase complexes › Ubiquitin-protein ligases › The rice peroxisomal receptor PEX5 negatively...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on aldehyde or oxo group donors › Aldehyde oxidoreductases › Aldehyde dehydrogenase › The rice peroxisomal receptor PEX5 negatively...
questionsmedicales.fr › Phénomènes physiologiques des plantes › Maladies des plantes › The rice peroxisomal receptor PEX5 negatively...
questionsmedicales.fr › Phénomènes physiologiques des plantes › Immunité des plantes › Résistance à la maladie › The rice peroxisomal receptor PEX5 negatively...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines végétales › The rice peroxisomal receptor PEX5 negatively...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes végétaux › The rice peroxisomal receptor PEX5 negatively...