Nucleoside Analogs: A Review of Its Source and Separation Processes.
molecular imprinting techniques
nucleoside analogs
selective separation and purification
separation methods
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
12 Oct 2023
12 Oct 2023
Historique:
received:
20
09
2023
revised:
09
10
2023
accepted:
10
10
2023
medline:
30
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
Nucleoside analogs play a crucial role in the production of high-value antitumor and antimicrobial drugs. Currently, nucleoside analogs are mainly obtained through nucleic acid degradation, chemical synthesis, and biotransformation. However, these methods face several challenges, such as low concentration of the main product, the presence of complex matrices, and the generation of numerous by-products that significantly limit the development of new drugs and their pharmacological studies. Therefore, this work aims to summarize the universal separation methods of nucleoside analogs, including crystallization, high-performance liquid chromatography (HPLC), column chromatography, solvent extraction, and adsorption. The review also explores the application of molecular imprinting techniques (MITs) in enhancing the identification of the separation process. It compares existing studies reported on adsorbents of molecularly imprinted polymers (MIPs) for the separation of nucleoside analogs. The development of new methods for selective separation and purification of nucleosides is vital to improving the efficiency and quality of nucleoside production. It enables us to obtain nucleoside products that are essential for the development of antitumor and antiviral drugs. Additionally, these methods possess immense potential in the prevention and control of serious diseases, offering significant economic, social, and scientific benefits to the fields of environment, biomedical research, and clinical therapeutics.
Identifiants
pubmed: 37894522
pii: molecules28207043
doi: 10.3390/molecules28207043
pmc: PMC10608831
pii:
doi:
Substances chimiques
Nucleosides
0
Polymers
0
Molecularly Imprinted Polymers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : the National Natural Science Foundation of China
ID : 22108103
Organisme : the National Natural Science Foundation of China
ID : 22078132
Organisme : the National Natural Science Foundation of China
ID : the National Natural Science Foundation of China
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