Systematic Screening of the Chemical Constituents of Lanqin Oral Liquid by Ultra-High-Performance Liquid Chromatography Combined with Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.
Lanqin oral liquid
UHPLC-FT-ICR-MS
chemical constituents
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
12 Oct 2023
12 Oct 2023
Historique:
received:
27
08
2023
revised:
23
09
2023
accepted:
09
10
2023
medline:
30
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
A rapid and sensitive method that combined ultra-high-performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry (UHPLC-FT-ICR-MS) was used to identify the chemical constituents in Lanqin oral liquid. On the basis of UHPLC-FT-ICR-MS analysis, systematic characterization of the chemical profile of Lanqin oral liquid was carried out, and a total of 441 compounds were identified or tentatively characterized including alkaloids, flavonoids, terpenoids, organic acids, phenylpropanoids, and other types. The results provide a reference for improving quality control, contribute to establishing higher quality standards, provide a scientific basis for further research on the pharmacodynamic material basis, and help illustrate the relationship between the complicated constituents and therapeutic effects of Lanqin oral liquid.
Identifiants
pubmed: 37894534
pii: molecules28207053
doi: 10.3390/molecules28207053
pmc: PMC10608861
pii:
doi:
Substances chimiques
Drugs, Chinese Herbal
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : grant number 82003935
Organisme : Basic Scientific Research Project of Education Department of Liaoning Province
ID : grant number LJKQZ20222409
Organisme : Natural Science Foundation of Liaoning Province
ID : grant number 2023-MS-326
Organisme : Startup Foundation for Docotors of Shenyang Medical College
ID : grant number 20195077
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