Environmental Endocrinology: Parabens Hazardous Effects on Hypothalamic-Pituitary-Thyroid Axis.
endocrine disruptor
hypothalamus–pituitary–thyroid axis
parabens
thyroid
toxicity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Oct 2023
17 Oct 2023
Historique:
received:
10
08
2023
revised:
28
09
2023
accepted:
08
10
2023
medline:
30
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
Parabens are classified as endocrine-disrupting chemicals (EDCs) capable of interfering with the normal functioning of the thyroid, affecting the proper regulation of the biosynthesis of thyroid hormones (THs), which is controlled by the hypothalamic-pituitary-thyroid axis (HPT). Given the crucial role of these hormones in health and the growing evidence of diseases related to thyroid dysfunction, this review looks at the effects of paraben exposure on the thyroid. In this study, we considered research carried out in vitro and in vivo and epidemiological studies published between 1951 and 2023, which demonstrated an association between exposure to parabens and dysfunctions of the HPT axis. In humans, exposure to parabens increases thyroid-stimulating hormone (TSH) levels, while exposure decreases TSH levels in rodents. The effects on THs levels are also poorly described, as well as peripheral metabolism. Regardless, recent studies have shown different actions between different subtypes of parabens on the HPT axis, which allows us to speculate that the mechanism of action of these parabens is different. Furthermore, studies of exposure to parabens are more evident in women than in men. Therefore, future studies are needed to clarify the effects of exposure to parabens and their mechanisms of action on this axis.
Identifiants
pubmed: 37894927
pii: ijms242015246
doi: 10.3390/ijms242015246
pmc: PMC10607526
pii:
doi:
Substances chimiques
Parabens
0
Thyroid Hormones
0
Hormones
0
Thyrotropin
9002-71-5
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
ID : CNE-FAPERJ E-26/200.798/2021
Organisme : Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
ID : Programa de Redes de Pesquisa em Saúde do Estado do Rio de Janeiro-2019 E-26/010.002429/2019
Organisme : Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
ID : Programa de Apoio a Projetos Temáticos no Estado do Rio de Janeiro E-26/211.265/2021
Organisme : Coordenação de Aperfeicoamento de Pessoal de Nível Superior
ID : DBCA grant 88887.683091/2022-00
Organisme : Coordenação de Aperfeicoamento de Pessoal de Nível Superior
ID : DSA grant 88887.683092/2022-00
Organisme : National Council for Scientific and Technological Development
ID : PQ2 310654/2021-1
Références
Curr Biol. 2014 May 19;24(10):R453-62
pubmed: 24845678
Endocr Relat Cancer. 2022 Dec 12;30(1):
pubmed: 36256851
J Clin Invest. 1967 Jan;46(1):57-64
pubmed: 6018750
Chemosphere. 2019 Mar;218:885-894
pubmed: 30609493
J Appl Toxicol. 2008 Jul;28(5):561-78
pubmed: 18484575
Sci Rep. 2020 Sep 24;10(1):15646
pubmed: 32973319
Environ Res. 2023 Feb 1;218:114869
pubmed: 36460069
Eur Thyroid J. 2013 Sep;2(3):160-7
pubmed: 24847449
Front Endocrinol (Lausanne). 2021 Jan 19;11:612320
pubmed: 33542707
Mol Cell Endocrinol. 2017 Dec 15;458:6-15
pubmed: 28153798
Toxicology. 2017 Feb 15;377:25-37
pubmed: 27916585
Environ Health Perspect. 2011 Feb;119(2):252-7
pubmed: 20876036
Front Pediatr. 2021 Feb 02;8:600962
pubmed: 33634051
Environ Sci Technol. 2012 Nov 6;46(21):11584-93
pubmed: 23025715
Front Endocrinol (Lausanne). 2019 Mar 21;10:178
pubmed: 30984107
Swiss Med Wkly. 2012 Aug 17;142:w13659
pubmed: 22903797
Endocrinology. 1992 May;130(5):2917-23
pubmed: 1572303
FEBS Lett. 1985 Jul 1;186(1):107-10
pubmed: 3924659
J Epidemiol Glob Health. 2019 Dec;9(4):217-222
pubmed: 31854162
Endocrinology. 1997 Jun;138(6):2227-32
pubmed: 9165005
Environ Res. 2016 Nov;151:30-37
pubmed: 27448730
Chemosphere. 2020 Feb;241:125118
pubmed: 31683416
Food Chem Toxicol. 2005 Jul;43(7):985-1015
pubmed: 15833376
Toxicol Lett. 2018 Mar 15;285:81-86
pubmed: 29305326
Eur J Biochem. 1976 Nov 15;70(2):435-40
pubmed: 1009939
J Clin Endocrinol Metab. 2010 Jan;95(1):375-82
pubmed: 19952225
Comp Biochem Physiol C Toxicol Pharmacol. 2022 Apr;254:109279
pubmed: 35077874
Toxicol Mech Methods. 2019 Nov;29(9):633-643
pubmed: 31354016
Environ Int. 2016 Mar;88:243-249
pubmed: 26773395
Curr Environ Health Rep. 2017 Dec;4(4):415-425
pubmed: 29027649
Environ Int. 2018 Apr;113:341-349
pubmed: 29366524
Eur J Endocrinol. 2004 Jan;150(1):73-80
pubmed: 14713282
Arch Toxicol. 2016 Nov;90(11):2699-2709
pubmed: 26608183
J Biol Chem. 2005 Aug 26;280(34):30046-54
pubmed: 15972824
PLoS One. 2016 May 25;11(5):e0155762
pubmed: 27223697
Endocr Relat Cancer. 2010 Jan 29;17(1):27-37
pubmed: 19779036
Birth Defects Res B Dev Reprod Toxicol. 2008 Apr;83(2):123-33
pubmed: 18393383
Chem Biol Interact. 2023 Apr 25;375:110428
pubmed: 36868496
Front Endocrinol (Lausanne). 2023 Jan 04;13:1092837
pubmed: 36686463
Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):249-59
pubmed: 17315033
J Biochem Mol Toxicol. 2020 Jun 3;:e22521
pubmed: 32492287
Environ Toxicol Pharmacol. 2015 Jul;40(1):241-58
pubmed: 26164742
Nat Rev Endocrinol. 2020 Jan;16(1):45-57
pubmed: 31719706
J Hazard Mater. 2017 Feb 5;323(Pt A):177-183
pubmed: 27156397
Oxid Med Cell Longev. 2019 Jan 9;2019:2514312
pubmed: 30728883
Mol Cell Endocrinol. 2021 Dec 1;538:111470
pubmed: 34606965
Dermatitis. 2019 Jan/Feb;30(1):32-45
pubmed: 30570577
Endocr Rev. 1995 Dec;16(6):752-64
pubmed: 8747834
Environ Res. 2018 Aug;165:379-386
pubmed: 29803919
Environ Pollut. 2019 Dec;255(Pt 2):113142
pubmed: 31563777
Environ Health. 2019 Apr 2;18(1):28
pubmed: 30940137
Int J Environ Res Public Health. 2020 Oct 24;17(21):
pubmed: 33114343
Nat Rev Endocrinol. 2018 May;14(5):301-316
pubmed: 29569622
Environ Int. 2023 Mar;173:107840
pubmed: 36857904
Mol Cell Endocrinol. 2018 Jan 15;460:246-257
pubmed: 28774778
Water Res. 2015 Jan 1;68:1-11
pubmed: 25462712
Drug Metab Pharmacokinet. 2010;25(6):568-77
pubmed: 20930423
Environ Sci Technol. 2022 Jan 4;56(1):460-469
pubmed: 34930008
Environ Toxicol. 2017 Jun;32(6):1801-1812
pubmed: 28181406
Reprod Toxicol. 2013 Jan;35:96-101
pubmed: 22789395
Oxid Med Cell Longev. 2013;2013:218145
pubmed: 24386502
Regul Toxicol Pharmacol. 2015 Nov;73(2):544-51
pubmed: 26359141
Environ Int. 2020 Jul;140:105783
pubmed: 32464474
Free Radic Biol Med. 2014 Aug;73:190-200
pubmed: 24853759
Toxicol Lett. 2006 May 25;163(2):130-41
pubmed: 16280211
Int J Hyg Environ Health. 2013 Nov;216(6):772-83
pubmed: 23528233
Sci Total Environ. 2013 Feb 15;445-446:299-305
pubmed: 23340023
Endocrine. 2022 Dec;78(3):395-405
pubmed: 35604630
Int J Toxicol. 2008;27 Suppl 4:1-82
pubmed: 19101832
Endocr Relat Cancer. 2020 Apr;27(4):245-259
pubmed: 32045361
Environ Health Perspect. 2006 Dec;114(12):1843-6
pubmed: 17185273
J Biol Chem. 1997 Oct 24;272(43):27230-8
pubmed: 9341168
Reprod Toxicol. 2010 Sep;30(2):301-12
pubmed: 20381602
Thyroid. 2013 Jan;23(1):111-9
pubmed: 23033809
Acta Paediatr. 2012 Aug;101(8):811-8
pubmed: 22458970
Environ Int. 2013 Jul;57-58:68-74
pubmed: 23685225
Environ Sci Pollut Res Int. 2022 Oct;29(46):70125-70134
pubmed: 35581467
Mol Cell Endocrinol. 2018 Oct 15;474:238-251
pubmed: 29596967
Environ Res. 2020 Sep;188:109710
pubmed: 32521303
Toxicol Sci. 2008 Nov;106(1):206-13
pubmed: 18648085
J Appl Toxicol. 2019 Sep;39(9):1248-1256
pubmed: 31066086
Toxicol Sci. 2003 Aug;74(2):231-2
pubmed: 12832657
Crit Rev Toxicol. 2007 Jan-Feb;37(1-2):11-53
pubmed: 17364704
Environ Sci Technol. 2013 Dec 17;47(24):14442-9
pubmed: 24261694
Horm Res Paediatr. 2020;93(6):361-370
pubmed: 33311025
Int J Androl. 2008 Apr;31(2):118-30
pubmed: 18194284
Chem Biol Interact. 2014 Sep 25;221:119-26
pubmed: 25108122
Nature. 2020 Feb;578(7796):627-630
pubmed: 32025030
Nat Rev Endocrinol. 2019 Jun;15(6):323-338
pubmed: 30886364
J Thyroid Res. 2012;2012:351864
pubmed: 23365787
Ecotoxicol Environ Saf. 2023 Jan 15;250:114502
pubmed: 36603489
FEBS Lett. 1981 Sep 14;132(1):29-32
pubmed: 7297685
Environ Pollut. 2015 Oct;205:145-52
pubmed: 26057477
Chem Biol Interact. 2014 Dec 5;224:164-75
pubmed: 25452175
Biochimie. 1999 May;81(5):505-9
pubmed: 10403182
Endocr Relat Cancer. 2013 Mar 22;20(2):R19-29
pubmed: 23319493
Mol Cell Endocrinol. 2020 Dec 1;518:110997
pubmed: 32841708
Adv Pharmacol. 2021;92:101-150
pubmed: 34452685
Environ Health Perspect. 2013 Oct;121(10):1225-31
pubmed: 23942273
Endocr Relat Cancer. 2009 Sep;16(3):845-56
pubmed: 19509065
Toxicology. 2020 Oct;443:152562
pubmed: 32798586
ISRN Toxicol. 2013 Dec 17;2013:507897
pubmed: 24455315
Toxicol Sci. 2007 Jun;97(2):308-17
pubmed: 17379623
Compr Physiol. 2016 Jun 13;6(3):1221-37
pubmed: 27347891
Environ Int. 2020 Jun;139:105716
pubmed: 32283359
Mol Aspects Med. 2011 Aug;32(4-6):234-46
pubmed: 22020111
Environ Res. 2022 Apr 15;206:112376
pubmed: 34798118
Reprod Toxicol. 2010 Jun;29(3):306-16
pubmed: 20132880