Extracellular Signal-Regulated Kinases Play Essential but Contrasting Roles in Osteoclast Differentiation.
bone
extracellular signal-regulated kinases (ERKs)
macrophage colony-stimulating factor (M-CSF)
mitogen-activated protein kinases (MAPKs)
osteoclast
receptor activator of nuclear factor kappa-B ligand (RANKL)
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Oct 2023
19 Oct 2023
Historique:
received:
22
09
2023
revised:
16
10
2023
accepted:
17
10
2023
medline:
30
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
Bone homeostasis is regulated by the balanced actions of osteoblasts that form the bone and osteoclasts (OCs) that resorb the bone. Bone-resorbing OCs are differentiated from hematopoietic monocyte/macrophage lineage cells, whereas osteoblasts are derived from mesenchymal progenitors. OC differentiation is induced by two key cytokines, macrophage colony-stimulating factor (M-CSF), a factor essential for the proliferation and survival of the OCs, and receptor activator of nuclear factor kappa-B ligand (RANKL), a factor for responsible for the differentiation of the OCs. Mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinases (ERKs), p38, and c-Jun N-terminal kinases, play an essential role in regulating the proliferation, differentiation, and function of OCs. ERKs have been known to play a critical role in the differentiation and activation of OCs. In most cases, ERKs positively regulate OC differentiation and function. However, several reports present conflicting conclusions. Interestingly, the inhibition of OC differentiation by ERK1/2 is observed only in OCs differentiated from RAW 264.7 cells. Therefore, in this review, we summarize the current understanding of the conflicting actions of ERK1/2 in OC differentiation.
Identifiants
pubmed: 37895023
pii: ijms242015342
doi: 10.3390/ijms242015342
pmc: PMC10607827
pii:
doi:
Substances chimiques
Extracellular Signal-Regulated MAP Kinases
EC 2.7.11.24
Cytokines
0
Macrophage Colony-Stimulating Factor
81627-83-0
RANK Ligand
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Inha University Research Grant
ID : none
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