The Role of IgLON Cell Adhesion Molecules in Neurodegenerative Diseases.
Alzheimer’s disease
Huntington’s disease
IgLON5
LSAMP
NEGR1
NEUROTRIMIN
Niemann-Pick disease
OPCML
Synucleinopathies
psychiatric disorders
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
28 09 2023
28 09 2023
Historique:
received:
01
09
2023
revised:
26
09
2023
accepted:
27
09
2023
medline:
30
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
In the brain, cell adhesion molecules (CAMs) are critical for neurite outgrowth, axonal fasciculation, neuronal survival and migration, and synapse formation and maintenance. Among CAMs, the IgLON family comprises five members: Opioid Binding Protein/Cell Adhesion Molecule Like (OPCML or OBCAM), Limbic System Associated Membrane Protein (LSAMP), neurotrimin (NTM), Neuronal Growth Regulator 1 (NEGR1), and IgLON5. IgLONs exhibit three N-terminal C2 immunoglobulin domains; several glycosylation sites; and a glycosylphosphatidylinositol anchoring to the membrane. Interactions as homo- or heterodimers in
Identifiants
pubmed: 37895235
pii: genes14101886
doi: 10.3390/genes14101886
pmc: PMC10606101
pii:
doi:
Substances chimiques
Cell Adhesion Molecules
0
Immunoglobulins
0
OPCML protein, human
0
GPI-Linked Proteins
0
IgLON5 protein, human
0
Cell Adhesion Molecules, Neuronal
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Am J Med Genet A. 2013 Apr;161A(4):787-91
pubmed: 23495067
Neurol Genet. 2019 Feb 11;5(2):e310
pubmed: 30863791
J Neurosci. 1991 Feb;11(2):519-33
pubmed: 1992014
Neurol Neuroimmunol Neuroinflamm. 2019 Dec 11;7(2):
pubmed: 31826985
Nat Neurosci. 2021 Jul;24(7):954-963
pubmed: 34045744
Biochem Biophys Res Commun. 2013 Jan 4;430(1):413-8
pubmed: 23206697
J Mol Biol. 1998 May 1;278(2):457-79
pubmed: 9571064
Front Genet. 2018 Feb 16;9:42
pubmed: 29503661
Neurosci Lett. 2003 Dec 11;352(3):179-82
pubmed: 14625014
Methods Mol Biol. 2019;2044:273-289
pubmed: 31432419
Cereb Cortex. 1993 May-Jun;3(3):187-98
pubmed: 8324369
Biochim Biophys Acta Biomembr. 2020 May 1;1862(5):183206
pubmed: 31991120
Biochemistry. 2008 Sep 23;47(38):10132-54
pubmed: 18729387
Brain Res. 2006 Jul 19;1100(1):21-31
pubmed: 16769038
Mol Neurodegener. 2021 Jun 5;16(1):37
pubmed: 34090488
Mol Neurobiol. 2016 Sep;53(7):4787-97
pubmed: 26328540
J Neurocytol. 2001 Nov;30(11):927-37
pubmed: 12373100
Nat Rev Immunol. 2004 May;4(5):325-35
pubmed: 15122198
J Comp Neurol. 1996 Nov 11;375(2):289-302
pubmed: 8915831
Ann Neurol. 2020 Nov;88(5):1023-1027
pubmed: 32740999
Neurology. 2017 May 2;88(18):1736-1743
pubmed: 28381508
Am J Hum Genet. 2007 Jul;81(1):17-31
pubmed: 17564960
Mol Psychiatry. 2009 Jun;14(6):601-13
pubmed: 18268500
Brain. 2018 Sep 1;141(9):2772-2794
pubmed: 30059965
Cell Biochem Funct. 2009 Oct;27(7):496-8
pubmed: 19711485
Am J Med Genet B Neuropsychiatr Genet. 2016 Jul;171(5):733-47
pubmed: 27021288
J Neural Transm (Vienna). 2019 Jan;126(1):35-45
pubmed: 30610379
J Affect Disord. 2020 Mar 15;265:679-686
pubmed: 32090785
Sci Adv. 2020 Oct 2;6(40):
pubmed: 33008897
Neuroscience. 1989;28(2):455-74
pubmed: 2922110
Obesity (Silver Spring). 2012 Dec;20(12):2420-5
pubmed: 22627920
Nat Genet. 2016 Sep;48(9):1031-6
pubmed: 27479909
J Neuroinflammation. 2016 Sep 01;13(1):226
pubmed: 27586161
Front Cell Dev Biol. 2016 Feb 16;4:9
pubmed: 26909348
Front Neurosci. 2017 Feb 02;11:38
pubmed: 28210208
J Biol Chem. 2015 Feb 13;290(7):4330-42
pubmed: 25538237
Pharmacol Biochem Behav. 2019 Aug;183:87-97
pubmed: 31163180
EMBO J. 1989 Feb;8(2):489-95
pubmed: 2721489
Neural Plast. 2016;2016:6427537
pubmed: 27242933
Proteomics. 2018 Jan;18(1):
pubmed: 29087046
Cardiovasc Diabetol. 2012 Jul 13;11:48
pubmed: 22553958
Brain Res. 2008 Aug 11;1224:1-11
pubmed: 18602091
Biol Psychiatry. 2010 Jul 15;68(2):197-204
pubmed: 20385375
Autoimmun Rev. 2015 Nov;14(11):984-95
pubmed: 26117594
J Neurochem. 2002 Mar;80(6):941-8
pubmed: 11953444
Physiol Rep. 2014 Jul 30;2(7):
pubmed: 25077509
J Mol Neurosci. 2012 Feb;46(2):373-7
pubmed: 21833655
Nat Rev Neurosci. 2007 Jan;8(1):11-20
pubmed: 17133224
PLoS One. 2008 Aug 20;3(8):e2990
pubmed: 18714356
Mol Psychiatry. 2019 Aug;24(8):1189-1205
pubmed: 30651602
J Pediatr Genet. 2015 Mar;4(1):23-8
pubmed: 27617112
Structure. 2019 Jun 4;27(6):893-906.e9
pubmed: 30956130
Mult Scler Relat Disord. 2020 Nov;46:102537
pubmed: 33296963
PLoS One. 2012;7(7):e41537
pubmed: 22844493
J Neurosci. 1998 Nov 15;18(22):9409-19
pubmed: 9801379
Development. 1995 Apr;121(4):1161-72
pubmed: 7743928
Brain Res Dev Brain Res. 2000 Aug 30;122(2):183-91
pubmed: 10960687
Lancet Neurol. 2014 Jun;13(6):575-86
pubmed: 24703753
Nat Commun. 2015 Nov 27;6:8836
pubmed: 26611261
Int J Mol Sci. 2023 Mar 07;24(6):
pubmed: 36982145
Science. 1984 Jan 20;223(4633):299-301
pubmed: 6199842
Nat Genet. 2018 May;50(5):668-681
pubmed: 29700475
Sci Rep. 2021 Oct 1;11(1):19536
pubmed: 34599206
Gene. 1992 Aug 15;117(2):249-54
pubmed: 1339369
Obesity (Silver Spring). 2009 Dec;17(12):2254-7
pubmed: 19478790
Brain Res Bull. 2018 Jun;140:5-18
pubmed: 29605488
Hippocampus. 2000;10(6):632-44
pubmed: 11153709
Neurochem Int. 1996 Apr;28(4):373-9
pubmed: 8740443
Degener Neurol Neuromuscul Dis. 2012 Jul 04;2:65-77
pubmed: 30890880
Neurol Neuroimmunol Neuroinflamm. 2021 Feb 2;8(2):
pubmed: 33531378
J Neuropsychiatry Clin Neurosci. 2011 Winter;23(1):90-7
pubmed: 21304144
Semin Immunol. 2003 Aug;15(4):215-23
pubmed: 14690046
Psychiatry Res. 2014 Mar 30;215(3):797-8
pubmed: 24491686
Brain Res Mol Brain Res. 2000 Oct 20;82(1-2):84-94
pubmed: 11042360
Neuroscience. 2003;117(3):645-58
pubmed: 12617969
PLoS One. 2014 Nov 25;9(11):e113662
pubmed: 25423262
Mol Cell Neurosci. 2005 Aug;29(4):580-90
pubmed: 15946856
Neuroimage Clin. 2020;27:102359
pubmed: 32758801
Curr Opin Neurobiol. 2017 Aug;45:99-105
pubmed: 28558267
Cells. 2020 Jul 31;9(8):
pubmed: 32751911
Cell Rep. 2019 Oct 1;29(1):49-61.e7
pubmed: 31577955
Schizophr Res. 2016 Nov;177(1-3):98-107
pubmed: 27335180
Annu Rev Neurosci. 2007;30:451-74
pubmed: 17600523
J Psychiatr Res. 2013 Nov;47(11):1572-80
pubmed: 23962679
Front Mol Neurosci. 2017 Nov 15;10:378
pubmed: 29249937
J Cell Sci. 2004 Aug 1;117(Pt 17):3961-73
pubmed: 15265982
J Comp Neurol. 2020 Oct 15;528(15):2620-2635
pubmed: 32266715
Neurobiol Aging. 2012 Aug;33(8):1833-8
pubmed: 21621298
Am J Hum Genet. 2008 Feb;82(2):477-88
pubmed: 18252227
Behav Brain Res. 2011 Feb 2;217(1):21-31
pubmed: 20888367
Behav Brain Res. 2012 Mar 1;228(1):74-81
pubmed: 22155487
Nat Genet. 2009 Jan;41(1):25-34
pubmed: 19079261
Biol Psychiatry. 2021 Mar 15;89(6):627-636
pubmed: 33279206
PLoS Genet. 2007 May 11;3(5):e82
pubmed: 17500595
J Psychiatr Res. 2010 Sep;44(12):748-53
pubmed: 20185149
Mol Cell Neurosci. 2001 Apr;17(4):746-60
pubmed: 11312609
Evol Bioinform Online. 2018 May 21;14:1176934318775081
pubmed: 29844654
Cytogenet Genome Res. 2015;146(1):39-43
pubmed: 26112959
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4138-42
pubmed: 3012554
Neurosci Lett. 2014 May 7;568:12-6
pubmed: 24686180
Am J Med Genet A. 2015 Dec;167A(12):3019-30
pubmed: 26334118
Neurol Neuroimmunol Neuroinflamm. 2017 Jul 18;4(5):e385
pubmed: 28761904
Annu Rev Pathol. 2016 May 23;11:221-50
pubmed: 26907528
Annu Rev Cell Dev Biol. 2010;26:363-96
pubmed: 19575676
Sci Rep. 2023 May 15;13(1):7816
pubmed: 37188790
Cells. 2022 Apr 06;11(7):
pubmed: 35406805
Cells. 2021 Apr 08;10(4):
pubmed: 33917676
J Hum Genet. 2013 Aug;58(8):539-47
pubmed: 23677055
Mol Cell Neurosci. 2003 Nov;24(3):725-40
pubmed: 14664821
Front Mol Neurosci. 2018 Jan 29;11:8
pubmed: 29434535
Brain Res. 2007 Aug 24;1165:5-14
pubmed: 17658490
Neurosci Biobehav Rev. 2013 Dec;37(10 Pt 1):2372-4
pubmed: 23313644
Behav Brain Res. 2008 Apr 9;188(2):380-90
pubmed: 18199495
J Alzheimers Dis. 2018;64(4):1149-1161
pubmed: 30010129
Cell. 2002 Sep 20;110(6):673-87
pubmed: 12297042
J Cell Biol. 1999 May 17;145(4):865-76
pubmed: 10330412
Cancer Discov. 2012 Feb;2(2):156-71
pubmed: 22585860
Lancet Neurol. 2008 Aug;7(8):715-27
pubmed: 18635020
Nat Genet. 2018 Mar;50(3):381-389
pubmed: 29483656
J Neurosci. 1998 Nov 15;18(22):9312-25
pubmed: 9801370
J Comp Neurol. 2000 Aug 14;424(1):74-85
pubmed: 10888740
Front Mol Neurosci. 2018 Feb 09;11:30
pubmed: 29479305
Gene. 1995 Apr 3;155(2):213-7
pubmed: 7721093
Front Biosci. 2003 Sep 01;8:s1304-20
pubmed: 12957835
Mol Psychiatry. 2022 Jun;27(6):2849-2857
pubmed: 35296807
Acta Neuropathol. 2016 Oct;132(4):531-43
pubmed: 27358064
Nat Neurosci. 2019 Mar;22(3):343-352
pubmed: 30718901
Transl Psychiatry. 2012 Aug 14;2:e152
pubmed: 22892717
Neurobiol Dis. 2023 Feb;177:105997
pubmed: 36634823
Ann Indian Acad Neurol. 2021 Jan-Feb;24(1):78-80
pubmed: 33911383
J Neurosci. 1990 Jan;10(1):73-90
pubmed: 1688937
J Biol Chem. 1999 Mar 19;274(12):8224-30
pubmed: 10075727
J Neurosci. 1995 Mar;15(3 Pt 2):2141-56
pubmed: 7891157
Biochem Biophys Res Commun. 2017 Jan 22;482(4):1367-1374
pubmed: 27940359
Cell Biochem Funct. 2011 Mar;29(2):114-9
pubmed: 21321971
Front Mol Neurosci. 2018 May 14;11:158
pubmed: 29867350
J Neurosci. 1988 Dec;8(12):4653-61
pubmed: 3199199
Mol Psychiatry. 2018 May;23(5):1169-1180
pubmed: 29155802
Prog Neurobiol. 2000 Aug;61(6):611-48
pubmed: 10775799
Biol Psychiatry. 2010 Jul 15;68(2):187-96
pubmed: 20452571
Mol Cell Neurosci. 2017 Jun;81:4-11
pubmed: 27561442
Trends Neurosci. 2017 May;40(5):295-308
pubmed: 28359630
J Alzheimers Dis. 2013;33 Suppl 1:S141-4
pubmed: 22710914
Annu Rev Genet. 2018 Nov 23;52:567-590
pubmed: 30212237
J Neurobiol. 2002 Jun 5;51(3):190-204
pubmed: 11984841
Cell. 2006 Nov 17;127(4):831-46
pubmed: 17110340
Hum Mol Genet. 2009 Apr 15;18(8):1489-96
pubmed: 19164386
Front Neurol. 2019 Oct 02;10:1056
pubmed: 31632341
Mol Cell Proteomics. 2014 Mar;13(3):733-48
pubmed: 24382801
Neuron. 1995 Aug;15(2):287-97
pubmed: 7646886
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jan 15;35(1):154-60
pubmed: 21036197
Nat Genet. 2008 Sep;40(9):1053-5
pubmed: 18677311
Front Immunol. 2023 Mar 21;14:1151574
pubmed: 37033996
Behav Brain Res. 2017 Jan 15;317:311-318
pubmed: 27693610
Annu Rev Cell Dev Biol. 1997;13:425-56
pubmed: 9442880
J Alzheimers Dis. 2022;90(3):1233-1247
pubmed: 36213995
Brain Sci. 2022 Dec 10;12(12):
pubmed: 36552158
J Mol Biol. 2020 Sep 4;432(19):5287-5303
pubmed: 32710982
Sci Rep. 2017 Aug 11;7(1):7961
pubmed: 28801670
BMC Med Genet. 2008 Apr 23;9:34
pubmed: 18433483
Mol Psychiatry. 2020 Sep;25(9):1926-1945
pubmed: 32214206
Proc Natl Acad Sci U S A. 1992 May 1;89(9):3706-10
pubmed: 1570290
Nat Neurosci. 2007 Jan;10(1):19-26
pubmed: 17189949
World J Biol Psychiatry. 2023 Mar;24(3):254-259
pubmed: 35703085
Front Mol Neurosci. 2016 Jan 13;8:89
pubmed: 26793057
J Neurosci. 1996 Mar 1;16(5):1770-9
pubmed: 8774445
J Psychosom Res. 2022 Nov;162:111032
pubmed: 36137488
Mol Neurodegener. 2015 Dec 01;10:64
pubmed: 26627638