The role and mechanisms of microvascular damage in the ischemic myocardium.


Journal

Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402

Informations de publication

Date de publication:
29 Oct 2023
Historique:
received: 22 05 2023
accepted: 02 10 2023
revised: 08 09 2023
medline: 31 10 2023
pubmed: 29 10 2023
entrez: 29 10 2023
Statut: epublish

Résumé

Following myocardial ischemic injury, the most effective clinical intervention is timely restoration of blood perfusion to ischemic but viable myocardium to reduce irreversible myocardial necrosis, limit infarct size, and prevent cardiac insufficiency. However, reperfusion itself may exacerbate cell death and myocardial injury, a process commonly referred to as ischemia/reperfusion (I/R) injury, which primarily involves cardiomyocytes and cardiac microvascular endothelial cells (CMECs) and is characterized by myocardial stunning, microvascular damage (MVD), reperfusion arrhythmia, and lethal reperfusion injury. MVD caused by I/R has been a neglected problem compared to myocardial injury. Clinically, the incidence of microvascular angina and/or no-reflow due to ineffective coronary perfusion accounts for 5-50% in patients after acute revascularization. MVD limiting drug diffusion into injured myocardium, is strongly associated with the development of heart failure. CMECs account for > 60% of the cardiac cellular components, and their role in myocardial I/R injury cannot be ignored. There are many studies on microvascular obstruction, but few studies on microvascular leakage, which may be mainly due to the lack of corresponding detection methods. In this review, we summarize the clinical manifestations, related mechanisms of MVD during myocardial I/R, laboratory and clinical examination means, as well as the research progress on potential therapies for MVD in recent years. Better understanding the characteristics and risk factors of MVD in patients after hemodynamic reconstruction is of great significance for managing MVD, preventing heart failure and improving patient prognosis.

Identifiants

pubmed: 37898977
doi: 10.1007/s00018-023-04998-z
pii: 10.1007/s00018-023-04998-z
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

341

Subventions

Organisme : National Natural Science Foundation of China
ID : U1903212
Organisme : National Natural Science Foundation of China
ID : 81870272
Organisme : Natural Science Foundation of Xinjiang Province
ID : 2021D04020
Organisme : the State Key Laboratory of Pathogenesis, Prevention and Treatment of Central Asia High Incidence Diseases fund
ID : SKL-HIDCA-2021-XXG1
Organisme : the State Key Laboratory of Pathogenesis, Prevention and Treatment of Central Asia High Incidence Diseases fund
ID : SKL-HIDCA-2022-XXG1

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.

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Auteurs

Bang-Hao Zhao (BH)

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology, the First Affiliated Hospital of Xinjiang Medical University, Clinical Medical Research Institute of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, China.
Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi, China.

Amanguli Ruze (A)

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology, the First Affiliated Hospital of Xinjiang Medical University, Clinical Medical Research Institute of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, China.
Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi, China.

Ling Zhao (L)

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology, the First Affiliated Hospital of Xinjiang Medical University, Clinical Medical Research Institute of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, China.
Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi, China.

Qiu-Lin Li (QL)

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology, the First Affiliated Hospital of Xinjiang Medical University, Clinical Medical Research Institute of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, China.
Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi, China.

Jing Tang (J)

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology, the First Affiliated Hospital of Xinjiang Medical University, Clinical Medical Research Institute of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, China.
Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi, China.

Nilupaer Xiefukaiti (N)

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology, the First Affiliated Hospital of Xinjiang Medical University, Clinical Medical Research Institute of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, China.
Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi, China.

Min-Tao Gai (MT)

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology, the First Affiliated Hospital of Xinjiang Medical University, Clinical Medical Research Institute of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, China.
Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi, China.

An-Xia Deng (AX)

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology, the First Affiliated Hospital of Xinjiang Medical University, Clinical Medical Research Institute of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, China.
Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi, China.

Xue-Feng Shan (XF)

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology, the First Affiliated Hospital of Xinjiang Medical University, Clinical Medical Research Institute of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, China.
Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi, China.

Xiao-Ming Gao (XM)

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology, the First Affiliated Hospital of Xinjiang Medical University, Clinical Medical Research Institute of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, China. xiaoming.gao@xjmu.edu.cn.
Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi, China. xiaoming.gao@xjmu.edu.cn.

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