Synthesis, anti-inflammatory activity, inverse molecular docking, and acid dissociation constants of new naphthoquinone-thiazole hybrids.
Acid dissociation constants
Anti-inflammatory activity
Inverse molecular docking
Naphthoquinone
Thiazole
Journal
Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298
Informations de publication
Date de publication:
15 11 2023
15 11 2023
Historique:
received:
06
10
2023
revised:
26
10
2023
accepted:
30
10
2023
medline:
14
11
2023
pubmed:
6
11
2023
entrez:
5
11
2023
Statut:
ppublish
Résumé
Chronic Inflammation is associated with various types of diseases that involves pro-inflammatory cytokines like IL-6 and TNF-α. High costs and serious side effects of available anti-inflammatory/immunomodulatory drugs led us to design new compounds with promising anti-inflammatory activities. Many drugs and biologically important compounds involve naphthoquinone and thiazole moieties in their core structures. Thereby, here we report the synthesis, characterization and anti-inflammatory activities of new naphthoquinone thiazole hybrids by reaction of naphthoquinone acyl thioureas with various α-bromoketone derivatives. The position of NO
Identifiants
pubmed: 37926047
pii: S0968-0896(23)00358-9
doi: 10.1016/j.bmc.2023.117510
pii:
doi:
Substances chimiques
Tumor Necrosis Factor-alpha
0
Thiazoles
0
Interleukin-6
0
Naphthoquinones
0
Lipopolysaccharides
0
Anti-Inflammatory Agents
0
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
117510Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.