Self-assembly of alkylated lysine-dendron oxytocin amphiphiles for enhanced stability and sustained pharmacological activity.

Humans Oxytocin / pharmacology Dendrimers / pharmacology Lysine Receptors, Oxytocin Nanoparticles

Journal

Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838

Informations de publication

Date de publication:
21 Nov 2023
Historique:
medline: 22 11 2023
pubmed: 6 11 2023
entrez: 6 11 2023
Statut: epublish

Résumé

Herein, we designed alkylated lysine-dendron oxytocin amphiphiles (ALOAs) 1G-OTK and 2G-OTK, which were self-assembled into spherical nanoparticles and nanostrips, respectively, and showed superior stability compared to native oxytocin. We found similar trends in the functional activity of ALOAs and native OT for human oxytocin receptor. This work may inspire the development of peptide drugs for clinical applications.

Identifiants

DOI: 10.1039/d3cc03801g PMID: 37927091
pubmed: 37927091
doi: 10.1039/d3cc03801g
doi:

Substances chimiques

Oxytocin 50-56-6
Dendrimers 0
Lysine K3Z4F929H6
Receptors, Oxytocin 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

13855-13858

Auteurs

Fengjuan Xie (F)

School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, P. R. China. jjwan@chem.ecnu.edu.cn.

Yingying Lin (Y)

School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, P. R. China. jjwan@chem.ecnu.edu.cn.

Åsa Andersson (Å)

Institute of Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia.

Irina Vetter (I)

Institute of Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia.
School of Pharmacy, The University of Queensland, Woolloongabba, QLD 4102, Australia.

Liang Zhao (L)

School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, P. R. China. jjwan@chem.ecnu.edu.cn.

JingJing Wan (J)

School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, P. R. China. jjwan@chem.ecnu.edu.cn.
ORCID: 0000-0001-9324-2647

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Self-assembly of alkylated lysine-dendron...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones hypophysaires › Hormones post-hypophysaires › Ocytocine › Self-assembly of alkylated lysine-dendron...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Dendrimères › Self-assembly of alkylated lysine-dendron...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Lysine › Self-assembly of alkylated lysine-dendron...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone hypophysaire › Récepteurs à l'ocytocine › Self-assembly of alkylated lysine-dendron...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Self-assembly of alkylated lysine-dendron...