AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity.
Journal
Current opinion in immunology
ISSN: 1879-0372
Titre abrégé: Curr Opin Immunol
Pays: England
ID NLM: 8900118
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
30
06
2023
revised:
09
10
2023
accepted:
09
10
2023
medline:
27
11
2023
pubmed:
7
11
2023
entrez:
6
11
2023
Statut:
ppublish
Résumé
The proper functioning of cytotoxic lymphocytes, such as natural killer and CD8+ T cells, is essential for effective cancer-immunity and immunotherapy responses. The differentiation of these cells is controlled by several transcription factors (TFs), including members of the activator protein (AP)-1 family. The activity of AP-1 family members is regulated by various immune signaling pathways, which can be triggered by activating or inhibitory receptors as well as cytokines. The target genes controlled by AP-1 TFs are central to generate immunity to pathogens or malignancies. Here, we provide an overview of the current understanding of how AP-1 TFs regulate cytotoxic lymphocytes.
Identifiants
pubmed: 37931499
pii: S0952-7915(23)00116-4
doi: 10.1016/j.coi.2023.102397
pii:
doi:
Substances chimiques
Transcription Factor AP-1
0
Antineoplastic Agents
0
Cytokines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102397Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest We confirm that the work is original research, has not been previously published, and has not been submitted for publication elsewhere. The authors declare no competing financial interests.