Bioprinting-Enabled Biomaterials: A Cutting-Edge Strategy for Future Osteoarthritis Therapy.


Journal

International journal of nanomedicine
ISSN: 1178-2013
Titre abrégé: Int J Nanomedicine
Pays: New Zealand
ID NLM: 101263847

Informations de publication

Date de publication:
2023
Historique:
received: 26 07 2023
accepted: 17 10 2023
medline: 8 11 2023
pubmed: 7 11 2023
entrez: 7 11 2023
Statut: epublish

Résumé

Bioprinting is an advanced technology that allows for the precise placement of cells and biomaterials in a controlled manner, making significant contributions in regenerative medicine. Notably, bioprinting-enabled biomaterials have found extensive application as drug delivery systems (DDS) in the treatment of osteoarthritis (OA). Despite the widespread utilization of these biomaterials, there has been limited comprehensive research summarizing the recent advances in this area. Therefore, this review aims to explore the noteworthy developments and challenges associated with utilizing bioprinting-enabled biomaterials as effective DDS for the treatment of OA. To begin, we provide an overview of the complex pathophysiology of OA, highlighting the shortcomings of current treatment modalities. Following this, we conduct a detailed examination of various bioprinting technologies and discuss the wide range of biomaterials employed in DDS applications for OA therapy. Finally, by placing emphasis on their transformative potential, we discuss the incorporation of crucial cellular components such as chondrocytes and mesenchymal stem cells into bioprinted constructs, which play a pivotal role in promoting tissue regeneration and repair.

Identifiants

pubmed: 37933298
doi: 10.2147/IJN.S432468
pii: 432468
pmc: PMC10625743
doi:

Substances chimiques

Biocompatible Materials 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

6213-6232

Informations de copyright

© 2023 Yang et al.

Déclaration de conflit d'intérêts

The authors report no conflicts of interest in this work.

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Auteurs

Xinquan Yang (X)

Department of Foot and Ankle Surgery, Honghui Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710054, People's Republic of China.

Peilong Liu (P)

Department of Foot and Ankle Surgery, Honghui Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710054, People's Republic of China.

Yan Zhang (Y)

Department of Foot and Ankle Surgery, Honghui Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710054, People's Republic of China.

Jun Lu (J)

Department of Foot and Ankle Surgery, Honghui Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710054, People's Republic of China.

Hongmou Zhao (H)

Department of Foot and Ankle Surgery, Honghui Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710054, People's Republic of China.

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