Regulation of the heterochromatin spreading reaction by
Silent Information Regulator
Suv39
gene silencing
heterochromatin spreading
polycomb
trans-acting factors
Journal
Open biology
ISSN: 2046-2441
Titre abrégé: Open Biol
Pays: England
ID NLM: 101580419
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
medline:
9
11
2023
pubmed:
8
11
2023
entrez:
7
11
2023
Statut:
ppublish
Résumé
Heterochromatin is a gene-repressive protein-nucleic acid ultrastructure that is initially nucleated by DNA sequences. However, following nucleation, heterochromatin can then propagate along the chromatin template in a sequence-independent manner in a reaction termed spreading. At the heart of this process are enzymes that deposit chemical information on chromatin, which attracts the factors that execute chromatin compaction and transcriptional or co/post-transcriptional gene silencing. Given that these enzymes deposit guiding chemical information on chromatin they are commonly termed 'writers'. While the processes of nucleation and central actions of writers have been extensively studied and reviewed, less is understood about how the spreading process is regulated. We discuss how the chromatin substrate is prepared for heterochromatic spreading, and how
Identifiants
pubmed: 37935357
doi: 10.1098/rsob.230271
pmc: PMC10645111
doi:
Substances chimiques
Trans-Activators
0
Heterochromatin
0
Histones
0
Chromatin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
230271Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM141888
Pays : United States
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