C-terminal modification and functionalization of proteins via a self-cleavage tag triggered by a small molecule.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
07 11 2023
07 11 2023
Historique:
received:
12
03
2023
accepted:
24
10
2023
medline:
9
11
2023
pubmed:
8
11
2023
entrez:
7
11
2023
Statut:
epublish
Résumé
The precise modification or functionalization of the protein C-terminus is essential but full of challenges. Herein, a chemical approach to modify the C-terminus is developed by fusing a cysteine protease domain on the C-terminus of the protein of interest, which could achieve the non-enzymatic C-terminal functionalization by InsP
Identifiants
pubmed: 37935692
doi: 10.1038/s41467-023-42977-x
pii: 10.1038/s41467-023-42977-x
pmc: PMC10630284
doi:
Substances chimiques
Protein C
0
Proteins
0
Cysteine Proteases
EC 3.4.-
Cysteine
K848JZ4886
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7169Informations de copyright
© 2023. The Author(s).
Références
J Am Chem Soc. 2021 Dec 1;143(47):19844-19855
pubmed: 34787412
Nat Commun. 2018 Jun 20;9(1):2411
pubmed: 29925835
J Am Chem Soc. 2019 Oct 30;141(43):17388-17393
pubmed: 31573802
Biomater Sci. 2023 Jan 31;11(3):719-748
pubmed: 36519403
J Biol Chem. 2016 Apr 22;291(17):9356-70
pubmed: 26966183
Chem Commun (Camb). 2021 Oct 14;57(82):10689-10702
pubmed: 34570125
Nat Rev Chem. 2023 Apr;7(4):234-255
pubmed: 37117416
Bioconjug Chem. 2016 Jan 20;27(1):47-53
pubmed: 26670641
Nat Commun. 2015 Dec 18;6:10199
pubmed: 26680698
J Am Chem Soc. 2023 Mar 29;145(12):6838-6844
pubmed: 36924109
Nat Chem. 2018 Feb;10(2):205-211
pubmed: 29359756
J Am Chem Soc. 2019 May 8;141(18):7294-7301
pubmed: 31017395
Bioconjug Chem. 2022 Dec 21;33(12):2341-2347
pubmed: 36356167
J Am Chem Soc. 2021 Nov 24;143(46):19498-19504
pubmed: 34761936
Angew Chem Int Ed Engl. 2020 Dec 7;59(50):22514-22522
pubmed: 32864829
J Am Chem Soc. 2017 Apr 19;139(15):5351-5358
pubmed: 28199119
Nat Chem Biol. 2009 Jul;5(7):469-78
pubmed: 19465933
Angew Chem Int Ed Engl. 2015 Dec 21;54(52):15694-8
pubmed: 26563575
Chem Sci. 2022 Jun 27;13(28):8289-8296
pubmed: 35919717
Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6705-10
pubmed: 9618476
J Am Chem Soc. 2021 Dec 8;143(48):20095-20108
pubmed: 34817989
BMC Biotechnol. 2017 Jan 5;17(1):1
pubmed: 28056928
J Am Chem Soc. 2009 Aug 12;131(31):10800-1
pubmed: 19610623
Bioconjug Chem. 2016 Nov 16;27(11):2592-2596
pubmed: 27723303
Bioconjug Chem. 2022 Jan 19;33(1):238-247
pubmed: 34985285
Bioconjug Chem. 2021 Aug 18;32(8):1570-1575
pubmed: 34232618
Science. 2008 Oct 10;322(5899):265-8
pubmed: 18845756
Chem Sci. 2020 May 12;11(23):5881-5888
pubmed: 32874509
Chem Commun (Camb). 2019 Jun 21;55(49):7029-7032
pubmed: 31140482
Org Biomol Chem. 2022 Jul 20;20(28):5638
pubmed: 35796104
Chem Rev. 2020 Mar 25;120(6):3051-3126
pubmed: 31774265
Nat Chem Biol. 2014 Sep;10(9):732-8
pubmed: 25038786
Chem Soc Rev. 2022 May 23;51(10):4121-4145
pubmed: 35510539
Angew Chem Int Ed Engl. 2020 Nov 23;59(48):21520-21524
pubmed: 32816380
Natl Sci Rev. 2021 Aug 24;9(5):nwab158
pubmed: 35663243
Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13787-91
pubmed: 26404067
Chem Rev. 2015 Mar 11;115(5):2174-95
pubmed: 25700113
J Biol Chem. 2008 Aug 29;283(35):23656-64
pubmed: 18591243
Bioconjug Chem. 2021 Nov 17;32(11):2397-2406
pubmed: 34748323
Chem Soc Rev. 2018 Dec 21;47(24):9106-9136
pubmed: 30259933
Angew Chem Int Ed Engl. 2022 Sep 5;61(36):e202204132
pubmed: 35737596
Nat Protoc. 2013 Dec;8(12):2483-95
pubmed: 24232250
PLoS One. 2009 Dec 02;4(12):e8119
pubmed: 19956581
Bioconjug Chem. 2011 Jun 15;22(6):1017-20
pubmed: 21618993
Nat Rev Drug Discov. 2003 Mar;2(3):214-21
pubmed: 12612647
J Am Chem Soc. 2020 Apr 15;142(15):7047-7054
pubmed: 32212692
Angew Chem Int Ed Engl. 2021 Feb 19;60(8):4004-4008
pubmed: 33202079
Chem Sci. 2014;5(1):446-461
pubmed: 24634716
J Am Chem Soc. 2014 Mar 5;136(9):3370-3
pubmed: 24533830