Synthesis, X-ray crystallography and antimicrobial activity of 2-cyanoguanidinophenytoin.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
09 11 2023
09 11 2023
Historique:
received:
08
06
2023
accepted:
20
10
2023
medline:
13
11
2023
pubmed:
10
11
2023
entrez:
9
11
2023
Statut:
epublish
Résumé
The optimized synthesis of [5-oxo-4,4-diphenylimidazolidin-2-ylidene]cyanamide, which is known as 2-cyanoguanidinophenytoin (CNG-DPH) (3), and (imidazo[4,5-d]imidazole-2,5-diylidine)dicyanamide (4) has been reported in the present work. Furthermore, new Mannich bases derived from CNG-DPH were synthesized via its reaction with formaldehyde and using the corresponding amines, piperidine (base 5), and morpholine (base 6). Also, the antimicrobial activity and X-ray crystal structures for CNG-DPH and their Mannich bases were studied. The bases 3 and 6 crystallized in a monoclinic system; the crystal structure of 3 containing four molecules in the unit cell with a P2
Identifiants
pubmed: 37945617
doi: 10.1038/s41598-023-45533-1
pii: 10.1038/s41598-023-45533-1
pmc: PMC10636160
doi:
Substances chimiques
2-cyanoguanidinophenytoin
0
Mannich Bases
0
Anti-Infective Agents
0
Morpholines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19510Informations de copyright
© 2023. The Author(s).
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