Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
23 Nov 2023
23 Nov 2023
Historique:
medline:
24
11
2023
pubmed:
10
11
2023
entrez:
10
11
2023
Statut:
ppublish
Résumé
There is an urgent need for new tuberculosis (TB) treatments, with novel modes of action, to reduce the incidence/mortality of TB and to combat resistance to current treatments. Through both chemical and genetic methodologies, polyketide synthase 13 (Pks13) has been validated as essential for mycobacterial survival and as an attractive target for
Identifiants
pubmed: 37948640
doi: 10.1021/acs.jmedchem.3c01514
pmc: PMC10683028
doi:
Substances chimiques
Polyketide Synthases
79956-01-7
Antitubercular Agents
0
Benzofurans
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
15380-15408Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
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