Origin of the enantioselectivity of alcohol dehydrogenase.

Alcohol Dehydrogenase / chemistry Alcohols Aldehydes Catalysis Ketones / chemistry Substrate Specificity

Journal

Physical chemistry chemical physics : PCCP
ISSN: 1463-9084
Titre abrégé: Phys Chem Chem Phys
Pays: England
ID NLM: 100888160

Informations de publication

Date de publication:
22 Nov 2023
Historique:
medline: 27 11 2023
pubmed: 13 11 2023
entrez: 13 11 2023
Statut: epublish

Résumé

Alcohol dehydrogenases (ADH) are a family of enzymes that catalyse the interconversion between ketones/aldehydes and alcohols in the presence of NADPH cofactor. It is challenging to desymmetrise the substituted cyclopentane-1,3-dione by engineering an ADH, while the reaction mechanism of the metal independent ADH remains elusive. Here we measured the conversion of a model substrate 2-benzyl-2-methylcyclopentane-1,3-dione by

Identifiants

DOI: 10.1039/d3cp04019d PMID: 37955422
pubmed: 37955422
doi: 10.1039/d3cp04019d
doi:

Substances chimiques

Alcohol Dehydrogenase EC 1.1.1.1
Alcohols 0
Aldehydes 0
Ketones 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

31292-31300

Auteurs

Jiahui Zhou (J)

School of Chemistry and Chemical Engineering, Queen's University, David Keir Building, Stranmillis Road, Belfast BT9 5AG, Northern Ireland, UK. m.huang@qub.ac.uk.

Tao Han (T)

Department of Chemistry, Zhejiang University, Hangzhou, 310027, P. R. China. wuqi1000@163.com.

Shahbaz Ahmad (S)

School of Chemistry and Chemical Engineering, Queen's University, David Keir Building, Stranmillis Road, Belfast BT9 5AG, Northern Ireland, UK. m.huang@qub.ac.uk.
Almac Sciences, Department of Biocatalysis and Isotope Chemistry, Almac House, 20 Seagoe Industrial Estate, Craigavon BT63 5QD, Northern Ireland, UK.
Arran Chemical Company Limited, Unit 1 Monksland Industrial Estate, Athlone, Co. Roscommon, Ireland.
ORCID: 0000-0003-1914-3135

Derek Quinn (D)

Almac Sciences, Department of Biocatalysis and Isotope Chemistry, Almac House, 20 Seagoe Industrial Estate, Craigavon BT63 5QD, Northern Ireland, UK.
Arran Chemical Company Limited, Unit 1 Monksland Industrial Estate, Athlone, Co. Roscommon, Ireland.

Thomas S Moody (TS)

Almac Sciences, Department of Biocatalysis and Isotope Chemistry, Almac House, 20 Seagoe Industrial Estate, Craigavon BT63 5QD, Northern Ireland, UK.
Arran Chemical Company Limited, Unit 1 Monksland Industrial Estate, Athlone, Co. Roscommon, Ireland.

Qi Wu (Q)

Department of Chemistry, Zhejiang University, Hangzhou, 310027, P. R. China. wuqi1000@163.com.
ORCID: 0000-0001-9386-8068

Meilan Huang (M)

School of Chemistry and Chemical Engineering, Queen's University, David Keir Building, Stranmillis Road, Belfast BT9 5AG, Northern Ireland, UK. m.huang@qub.ac.uk.
ORCID: 0000-0001-9063-8056

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › Alcohol dehydrogenase › Origin of the enantioselectivity of alcohol...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Origin of the enantioselectivity of alcohol...
questionsmedicales.fr › Composés chimiques organiques › Aldéhydes › Origin of the enantioselectivity of alcohol...
questionsmedicales.fr › Phénomènes chimiques › Catalyse › Origin of the enantioselectivity of alcohol...
questionsmedicales.fr › Composés chimiques organiques › Cétones › Origin of the enantioselectivity of alcohol...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Spécificité du substrat › Origin of the enantioselectivity of alcohol...