Harmonization of multi-site diffusion tensor imaging data for cervical and thoracic spinal cord at 1.5 T and 3 T using longitudinal ComBat.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
13 11 2023
Historique:
received: 02 08 2023
accepted: 01 11 2023
medline: 15 11 2023
pubmed: 14 11 2023
entrez: 13 11 2023
Statut: epublish

Résumé

MRI scanner hardware, field strengths, and sequence parameters are major variables in diffusion studies of the spinal cord. Reliability between scanners is not well known, particularly for the thoracic cord. DTI data was collected for the entire cervical and thoracic spinal cord in thirty healthy adult subjects with different MR vendors and field strengths. DTI metrics were extracted and averaged for all slices within each vertebral level. Metrics were examined for variability and then harmonized using longitudinal ComBat (longComBat). Four scanners were used: Siemens 3 T Prisma, Siemens 1.5 T Avanto, Philips 3 T Ingenia, Philips 1.5 T Achieva. Average full cord diffusion values/standard deviation for all subjects and scanners were FA: 0.63, σ = 0.10, MD: 1.11, σ = 0.12 × 10

Identifiants

pubmed: 37957164
doi: 10.1038/s41598-023-46465-6
pii: 10.1038/s41598-023-46465-6
pmc: PMC10643628
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

19809

Informations de copyright

© 2023. The Author(s).

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Auteurs

Devon M Middleton (DM)

Department of Radiology, Thomas Jefferson University, 909 Walnut Street, First Floor COB, Philadelphia, PA, 19107, USA. dxm282@jefferson.edu.

Yutong Li (Y)

Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.

Andrew Chen (A)

Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, USA.

Russell Shinohara (R)

Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, USA.

Joshua Fisher (J)

Elsevier, Inc., Philadelphia, PA, USA.

Laura Krisa (L)

Department of Occupational Therapy, Thomas Jefferson University, Philadelphia, PA, USA.

Mark Elliot (M)

Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.

Scott H Faro (SH)

Department of Radiology, Thomas Jefferson University, 909 Walnut Street, First Floor COB, Philadelphia, PA, 19107, USA.

John H Woo (JH)

Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.

Adam E Flanders (AE)

Department of Radiology, Thomas Jefferson University, 909 Walnut Street, First Floor COB, Philadelphia, PA, 19107, USA.

Feroze B Mohamed (FB)

Department of Radiology, Thomas Jefferson University, 909 Walnut Street, First Floor COB, Philadelphia, PA, 19107, USA.

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