Protein aggregates act as a deterministic disruptor during bacterial cell size homeostasis.
Asymmetric septation
Bacillus subtilis
Binary fission
Escherichia coli
Protein aggregates
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
16 Nov 2023
16 Nov 2023
Historique:
received:
02
05
2023
accepted:
15
10
2023
revised:
13
10
2023
medline:
20
11
2023
pubmed:
17
11
2023
entrez:
16
11
2023
Statut:
epublish
Résumé
Mechanisms underlying deviant cell size fluctuations among clonal bacterial siblings are generally considered to be cryptic and stochastic in nature. However, by scrutinizing heat-stressed populations of the model bacterium Escherichia coli, we uncovered the existence of a deterministic asymmetry in cell division that is caused by the presence of intracellular protein aggregates (PAs). While these structures typically locate at the cell pole and segregate asymmetrically among daughter cells, we now show that the presence of a polar PA consistently causes a more distal off-center positioning of the FtsZ division septum. The resulting increased length of PA-inheriting siblings persists over multiple generations and could be observed in both E. coli and Bacillus subtilis populations. Closer investigation suggests that a PA can physically perturb the nucleoid structure, which subsequently leads to asymmetric septation.
Identifiants
pubmed: 37971522
doi: 10.1007/s00018-023-05002-4
pii: 10.1007/s00018-023-05002-4
doi:
Substances chimiques
Bacterial Proteins
0
Protein Aggregates
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
360Subventions
Organisme : Fonds Wetenschappelijk Onderzoek
ID : 11B0519N
Organisme : Fonds Wetenschappelijk Onderzoek
ID : 11J6222N
Organisme : Fonds Wetenschappelijk Onderzoek
ID : 1135116N
Organisme : Fonds Wetenschappelijk Onderzoek
ID : G0C7118N
Organisme : Fonds Wetenschappelijk Onderzoek
ID : G0D8220N
Organisme : Onderzoeksraad, KU Leuven
ID : PDM/20/118
Organisme : Onderzoeksraad, KU Leuven
ID : STG/21/068
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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