Minimal residual disease detection by next-generation sequencing of different immunoglobulin gene rearrangements in pediatric B-ALL.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
17 11 2023
17 11 2023
Historique:
received:
26
05
2023
accepted:
02
11
2023
medline:
20
11
2023
pubmed:
18
11
2023
entrez:
17
11
2023
Statut:
epublish
Résumé
While the prognostic role of immunoglobulin heavy chain locus (IGH) rearrangement in minimal residual disease (MRD) in pediatric B-acute lymphoblastic leukemia (B-ALL) has been reported, the contribution of light chain loci (IGK/IGL) remains elusive. This study is to evaluate the prognosis of IGH and IGK/IGL rearrangement-based MRD detected by next-generation sequencing in B-ALL at the end of induction (EOI) and end of consolidation (EOC). IGK/IGL rearrangements identify 5.5% of patients without trackable IGH clones. Concordance rates for IGH and IGK/IGL are 79.9% (cutoff 0.01%) at EOI and 81.0% (cutoff 0.0001%) at EOC, respectively. Patients with NGS-MRD < 0.01% at EOI or <0.0001% at EOC present excellent outcome, with 3-year event-free survival rates higher than 95%. IGH-MRD is prognostic at EOI/EOC, while IGK-MRD at EOI/EOC and IGL-MRD at EOI are not. At EOI, NGS identifies 26.2% of higher risk patients whose MRD < 0.01% by flow cytometry. However, analyzing IGK/IGL along with IGH fails to identify additional higher risk patients both at EOI and at EOC. In conclusion, IGH is crucial for MRD monitoring while IGK and IGL have relatively limited value.
Identifiants
pubmed: 37978187
doi: 10.1038/s41467-023-43171-9
pii: 10.1038/s41467-023-43171-9
pmc: PMC10656538
doi:
Substances chimiques
Immunoglobulin Heavy Chains
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7468Informations de copyright
© 2023. The Author(s).
Références
Eur J Cancer. 2013 Apr;49(6):1346-55
pubmed: 23265714
Blood. 2018 Mar 22;131(12):1350-1359
pubmed: 29284596
Blood Res. 2020 Jul 31;55(S1):S19-S26
pubmed: 32719172
JAMA Oncol. 2017 Jul 13;3(7):e170580
pubmed: 28494052
Arch Pathol Lab Med. 2022 Apr 1;146(4):485-493
pubmed: 34343238
Haematologica. 2012 Oct;97(10):1582-93
pubmed: 22581001
Blood Adv. 2023 Jul 25;7(14):3395-3402
pubmed: 37196642
Blood. 2018 May 17;131(20):2256-2261
pubmed: 29434033
J Natl Compr Canc Netw. 2020 Jan;18(1):81-112
pubmed: 31910389
Blood Cancer J. 2020 Oct 30;10(10):108
pubmed: 33127891
JAMA. 2021 Mar 2;325(9):843-854
pubmed: 33651091
Blood. 2012 Nov 22;120(22):4407-17
pubmed: 22932801
Leuk Res. 2012 Aug;36(8):1022-7
pubmed: 22483330
Blood. 2009 Feb 12;113(7):1408-11
pubmed: 18974371
Clin Cancer Res. 2014 Sep 1;20(17):4540-8
pubmed: 24970842
Leuk Res. 2017 Feb;53:1-7
pubmed: 27930944
BMC Cancer. 2020 Jun 30;20(1):612
pubmed: 32605647
Leukemia. 2019 Sep;33(9):2241-2253
pubmed: 31243313
Best Pract Res Clin Haematol. 2002 Mar;15(1):37-57
pubmed: 11987915
Best Pract Res Clin Haematol. 2020 Mar;33(1):101149
pubmed: 32139014
Blood. 2020 May 7;135(19):1639-1649
pubmed: 31961921
Bone Marrow Transplant. 2022 Aug;57(8):1350-1353
pubmed: 35650329
Leukemia. 2020 Sep;34(9):2418-2429
pubmed: 32099036
Br J Haematol. 2021 Jun;193(6):1096-1104
pubmed: 33764511
J Hematol Oncol. 2018 Aug 22;11(1):105
pubmed: 30134947
Blood. 2023 Feb 2;141(5):529-533
pubmed: 36240445
Blood Adv. 2023 Sep 12;7(17):4748-4759
pubmed: 36399518
Front Pediatr. 2022 May 30;10:874771
pubmed: 35712632
Blood. 2015 Jun 25;125(26):3996-4009
pubmed: 25999452
Leukemia. 2003 Sep;17(9):1834-44
pubmed: 12970784
Blood Cancer J. 2023 Mar 6;13(1):32
pubmed: 36878906
Blood Adv. 2022 Jul 12;6(13):4006-4014
pubmed: 35533262
Leukemia. 2008 Apr;22(4):771-82
pubmed: 18239620
Clin Cancer Res. 2017 Aug 1;23(15):3980-3993
pubmed: 28428191
Leukemia. 2010 Mar;24(3):521-35
pubmed: 20033054
Cancers (Basel). 2021 Apr 13;13(8):
pubmed: 33924381
Expert Rev Mol Diagn. 2019 Jul;19(7):571-578
pubmed: 31179776
J Mol Diagn. 2019 Mar;21(2):330-342
pubmed: 30590126
Blood. 2015 Aug 20;126(8):964-71
pubmed: 26124497
Lancet Oncol. 2015 Apr;16(4):465-74
pubmed: 25800893
Blood. 2015 May 28;125(22):3501-8
pubmed: 25862561
Br J Haematol. 2017 Jan;176(2):248-257
pubmed: 27861730
Lancet. 2020 Apr 4;395(10230):1146-1162
pubmed: 32247396
Blood. 2023 Feb 2;141(5):519-528
pubmed: 36084320