Membrane potential accelerates sugar uptake by stabilizing the outward facing conformation of the Na/glucose symporter vSGLT.

Symporters / metabolism Sugars Glucose Membrane Potentials Galactose / metabolism Electron Spin Resonance Spectroscopy Sodium-Glucose Transport Proteins / genetics Sodium / metabolism Protein Conformation

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
18 11 2023
Historique:
received: 08 09 2022
accepted: 30 10 2023
medline: 20 11 2023
pubmed: 19 11 2023
entrez: 19 11 2023
Statut: epublish

Résumé

Sodium-dependent glucose transporters (SGLTs) couple a downhill Na

Identifiants

DOI: 10.1038/s41467-023-43119-z PMID: 37980423 PMC: PMC10657379
pubmed: 37980423
doi: 10.1038/s41467-023-43119-z
pii: 10.1038/s41467-023-43119-z
pmc: PMC10657379
doi:

Substances chimiques

Symporters 0
Sugars 0
Glucose IY9XDZ35W2
Galactose X2RN3Q8DNE
Sodium-Glucose Transport Proteins 0
Sodium 9NEZ333N27

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

7511

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM089740
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM137081
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM137109
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM135175
Pays : United States

Informations de copyright

© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.

Références

Biophys J. 1997 Dec;73(6):2980-9
pubmed: 9414213
Nature. 2010 Dec 16;468(7326):988-91
pubmed: 21131949
Biophys Chem. 2010 Feb;146(2-3):133-7
pubmed: 20031298
Bioinformatics. 2013 Apr 1;29(7):845-54
pubmed: 23407358
J Chem Theory Comput. 2016 Jan 12;12(1):405-13
pubmed: 26631602
J Biomol Struct Dyn. 2000 Apr;17(5):811-9
pubmed: 10798526
Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3960-6
pubmed: 27325773
Annu Rev Phys Chem. 2012;63:419-46
pubmed: 22404592
Annu Rev Biochem. 1995;64:493-531
pubmed: 7574491
Biochim Biophys Acta. 2011 Feb;1807(2):167-88
pubmed: 21029721
Biochim Biophys Acta. 1987 Oct 16;903(3):480-94
pubmed: 2444259
Nature. 2022 Jan;601(7892):280-284
pubmed: 34880493
Science. 2008 Aug 8;321(5890):810-4
pubmed: 18599740
Magn Reson (Gott). 2020;1(2):209-224
pubmed: 34568875
Science. 1992 Mar 27;255(5052):1712-5
pubmed: 1553560
J Comput Chem. 2011 Jul 30;32(10):2319-27
pubmed: 21500218
Nat Commun. 2023 May 22;14(1):2920
pubmed: 37217492
Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4557-66
pubmed: 24191006
Biochem Biophys Res Commun. 1969 May 22;35(4):512-8
pubmed: 5788506
Phys Chem Chem Phys. 2013 Apr 28;15(16):5854-66
pubmed: 23487036
Nature. 2005 Aug 11;436(7052):848-51
pubmed: 16094368
Nature. 1999 Dec 16;402(6763):813-7
pubmed: 10617202
PLoS One. 2010 Sep 29;5(9):
pubmed: 20949122
J Gen Physiol. 2006 Dec;128(6):701-20
pubmed: 17130520
Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2742-E2751
pubmed: 29507231
J Gen Physiol. 1995 Dec;106(6):1053-68
pubmed: 8786350
J Phys Chem B. 2015 Mar 12;119(10):3901-11
pubmed: 25645890
Nature. 2022 Jan;601(7892):274-279
pubmed: 34880492
Nat Commun. 2018 Dec 7;9(1):5245
pubmed: 30532032
J Comput Chem. 2008 Aug;29(11):1859-65
pubmed: 18351591
Physiol Rev. 2011 Apr;91(2):733-94
pubmed: 21527736
Int J Mol Sci. 2021 Mar 30;22(7):
pubmed: 33808202
CPT Pharmacometrics Syst Pharmacol. 2022 Mar;11(3):290-301
pubmed: 35064965
Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10037-41
pubmed: 11517324
Structure. 2015 Aug 4;23(8):1526-1537
pubmed: 26118532
Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18497-18503
pubmed: 32680969
Nat Commun. 2018 May 1;9(1):1753
pubmed: 29717135
Nature. 1966 Aug 27;211(5052):969-70
pubmed: 5968307
Cell. 2022 Sep 29;185(20):3739-3752.e18
pubmed: 36113465
J Membr Biol. 1992 Jan;125(1):49-62
pubmed: 1542106
Physiology (Bethesda). 2009 Dec;24:377-86
pubmed: 19996368
Protein Sci. 2018 Jan;27(1):76-85
pubmed: 28799219
Nat Methods. 2017 Jan;14(1):71-73
pubmed: 27819658
J Comput Chem. 2014 Oct 15;35(27):1997-2004
pubmed: 25130509
Kidney360. 2021 Sep 17;2(12):2027-2037
pubmed: 35419546
Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9980-E9988
pubmed: 29087341

Auteurs

Farha Khan (F)

Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Department of Structural Biology, Van Andel Institute, Grand Rapids, MI, 49503, USA.

Matthias Elgeti (M)

Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA. melgeti@ucla.edu.
Institute for Drug Discovery, Leipzig University Medical School, Leipzig, Germany. melgeti@ucla.edu.
ORCID: 0000-0002-0550-4852

Samuel Grandfield (S)

Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, 11794, USA.
ORCID: 0000-0002-4512-6593

Aviv Paz (A)

Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Hauptman-Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, NY, 14203, USA.
ORCID: 0000-0003-0792-492X

Fiona B Naughton (FB)

Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94158, USA.

Frank V Marcoline (FV)

Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94158, USA.
ORCID: 0000-0002-8842-5470

Thorsten Althoff (T)

Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
ORCID: 0000-0001-5688-5328

Natalia Ermolova (N)

Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Ernest M Wright (EM)

Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
ORCID: 0000-0002-1023-4391

Wayne L Hubbell (WL)

Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Michael Grabe (M)

Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94158, USA. michael.grabe@ucsf.edu.
ORCID: 0000-0003-3509-5997

Jeff Abramson (J)

Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA. jabramson@mednet.ucla.edu.
ORCID: 0000-0003-0004-7426

Articles similaires

Membrane potential stimulates ADP import and ATP export by the mitochondrial ADP/ATP carrier due to its positively charged binding site.

Vasiliki Mavridou, Martin S King, Andre Bazzone et al.
1.00
Adenosine Triphosphate Adenosine Diphosphate Mitochondrial ADP, ATP Translocases Binding Sites Mitochondria

Rice growth and yield responses to saline water irrigation are related to Na+/K+ ratio in plants.

Priya Lal Chandra Paul, Afsana Jahan, Palash Kumar Kundu et al.
1.00
Oryza Agricultural Irrigation Potassium Sodium Soil

Structural basis for molecular assembly of fucoxanthin chlorophyll

Koji Kato, Yoshiki Nakajima, Jian Xing et al.
1.00
Diatoms Photosystem I Protein Complex Chlorophyll Binding Proteins Cryoelectron Microscopy Light-Harvesting Protein Complexes

Metabolic engineering of

Jae Sung Cho, Zi Wei Luo, Cheon Woo Moon et al.
1.00
Corynebacterium glutamicum Metabolic Engineering Dicarboxylic Acids Pyridines Pyrones

Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Symporteurs › Membrane potential accelerates sugar uptake by...
questionsmedicales.fr › Glucides › Sucres › Membrane potential accelerates sugar uptake by...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Membrane potential accelerates sugar uptake by...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Membrane potential accelerates sugar uptake by...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Galactose › Membrane potential accelerates sugar uptake by...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Spectroscopie de résonance de spin électronique › Membrane potential accelerates sugar uptake by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs de monosaccharides › Protéines de transport glucose-sodium › Membrane potential accelerates sugar uptake by...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Sodium › Membrane potential accelerates sugar uptake by...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Membrane potential accelerates sugar uptake by...