Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration.
developmental biology
light lesion
progenitors
regeneration
retina
scRNAseq
zebrafish
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
21 Nov 2023
21 Nov 2023
Historique:
medline:
23
11
2023
pubmed:
21
11
2023
entrez:
21
11
2023
Statut:
epublish
Résumé
In the lesioned zebrafish retina, Müller glia produce multipotent retinal progenitors that generate all retinal neurons, replacing lost cell types. To study the molecular mechanisms linking Müller glia reactivity to progenitor production and neuronal differentiation, we used single-cell RNA sequencing of Müller glia, progenitors and regenerated progeny from uninjured and light-lesioned retinae. We discover an injury-induced Müller glia differentiation trajectory that leads into a cell population with a hybrid identity expressing marker genes of Müller glia and progenitors. A glial self-renewal and a neurogenic trajectory depart from the hybrid cell population. We further observe that neurogenic progenitors progressively differentiate to generate retinal ganglion cells first and bipolar cells last, similar to the events observed during retinal development. Our work provides a comprehensive description of Müller glia and progenitor transcriptional changes and fate decisions in the regenerating retina, which are key to tailor cell differentiation and replacement therapies for retinal dystrophies in humans.
Identifiants
pubmed: 37988404
doi: 10.7554/eLife.86507
pii: 86507
pmc: PMC10662954
doi:
pii:
Banques de données
GEO
['GSE226373']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : BR 1746/11-1
Organisme : HORIZON EUROPE European Research Council
ID : ERC AdG Zf-BrainReg
Organisme : Deutsche Forschungsgemeinschaft
ID : EXC 168
Informations de copyright
© 2023, Celotto et al.
Déclaration de conflit d'intérêts
LC, FR, AM, JB, AD, AW, SH, MB No competing interests declared
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