A Novel mechanism of herbicide action through disruption of pyrimidine biosynthesis.

Dihydroorotate Dehydrogenase Oxidoreductases Acting on CH-CH Group Donors / metabolism Herbicides / pharmacology Pyrimidines / pharmacology Anilides Pyrrolidinones Enzyme Inhibitors / pharmacology
Novel herbicide action dihydroorotate dehydrogenase pyrimidine biosynthesis tetflupyrolimet

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
28 Nov 2023
Historique:
pmc-release: 21 05 2024
medline: 23 11 2023
pubmed: 21 11 2023
entrez: 21 11 2023
Statut: ppublish

Résumé

A lead aryl pyrrolidinone anilide identified using high-throughput in vivo screening was optimized for efficacy, crop safety, and weed spectrum, resulting in tetflupyrolimet. Known modes of action were ruled out through in vitro enzyme and in vivo plant-based assays. Genomic sequencing of aryl pyrrolidinone anilide-resistant

Identifiants

DOI: 10.1073/pnas.2313197120 PMID: 37988466 PMC: PMC10691210
pubmed: 37988466
doi: 10.1073/pnas.2313197120
pmc: PMC10691210
doi:

Substances chimiques

Dihydroorotate Dehydrogenase 0
Oxidoreductases Acting on CH-CH Group Donors EC 1.3.-
Herbicides 0
Pyrimidines 0
Anilides 0
Pyrrolidinones 0
Enzyme Inhibitors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2313197120

Commentaires et corrections

Type : CommentIn

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Références

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Auteurs

Il-Ho Kang (IH)

FMC Agricultural Solutions, Stine Research Center, Newark, DE 19711.

Ryan P Emptage (RP)

FMC Agricultural Solutions, Stine Research Center, Newark, DE 19711.

Sang-Ic Kim (SI)

FMC Agricultural Solutions, Stine Research Center, Newark, DE 19711.
ORCID: 0009-0005-6679-1604

Steven Gutteridge (S)

FMC Agricultural Solutions, Stine Research Center, Newark, DE 19711.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-CH group donors › Dihydroorotate dehydrogenase › A Novel mechanism of herbicide action through...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-CH group donors › A Novel mechanism of herbicide action through...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Pesticides › Herbicides › A Novel mechanism of herbicide action through...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › A Novel mechanism of herbicide action through...
questionsmedicales.fr › Composés chimiques organiques › Amines › Dérivés de l'aniline › Anilides › A Novel mechanism of herbicide action through...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrrolidines › Pyrrolidones › A Novel mechanism of herbicide action through...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › A Novel mechanism of herbicide action through...