Reduction of p11 in dorsal raphe nucleus serotonergic neurons mediates depression-like behaviors.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
22 Nov 2023
22 Nov 2023
Historique:
received:
08
08
2023
accepted:
09
11
2023
revised:
13
10
2023
medline:
24
11
2023
pubmed:
23
11
2023
entrez:
22
11
2023
Statut:
epublish
Résumé
The pathology of depression is related to the imbalance of various neurotransmitters. The dorsal raphe nucleus (DRN), the main brain region producing 5-HT, is crucially involved in the pathophysiology of depression. It contains several neuron types, in which GABAergic neurons are activated by stimuli associated with negative experiences and 5-HT neurons are activated by reward signals. However, little is known about its underlying molecular mechanisms. Here, we found that p11, a multifunctional protein associated with depression, was down-regulated by chronic social defeat stress in 5-HT
Identifiants
pubmed: 37993435
doi: 10.1038/s41398-023-02664-3
pii: 10.1038/s41398-023-02664-3
pmc: PMC10665321
doi:
Substances chimiques
Serotonin
333DO1RDJY
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
359Subventions
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 81973943
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82274643
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82104986
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82174499
Informations de copyright
© 2023. The Author(s).
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