Depletion of tRNA CCA-adding enzyme in Mycobacterium tuberculosis leads to polyadenylation of transcripts and precursor tRNAs.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 Nov 2023
24 Nov 2023
Historique:
received:
11
10
2023
accepted:
20
11
2023
medline:
27
11
2023
pubmed:
25
11
2023
entrez:
24
11
2023
Statut:
epublish
Résumé
In reference to gene annotation, more than half of the tRNA species synthesized by Mycobacterium tuberculosis require the enzymatic addition of the cytosine-cytosine-adenine (CCA) tail, which is indispensable for amino acid charging and tRNA functionality. It makes the mycobacterial CCA-adding enzyme essential for survival of the bacterium and a potential target for novel pipelines in drug discovery avenues. Here, we described the rv3907c gene product, originally annotated as poly(A)polymerase (rv3907c, PcnA) as a functional CCA-adding enzyme (CCA
Identifiants
pubmed: 38001315
doi: 10.1038/s41598-023-47944-6
pii: 10.1038/s41598-023-47944-6
pmc: PMC10673834
doi:
Substances chimiques
tRNA nucleotidyltransferase
EC 2.7.7.-
Adenine
JAC85A2161
Cytosine
8J337D1HZY
RNA Nucleotidyltransferases
EC 2.7.7.-
RNA, Transfer
9014-25-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
20717Subventions
Organisme : Narodowym Centrum Nauki
ID : UMO-2017/25/B/NZ7/01290
Organisme : Narodowym Centrum Nauki
ID : UMO-2019/34/E/NZ1/00338
Organisme : Narodowym Centrum Nauki
ID : UMO-2017/25/B/NZ7/01290
Organisme : Narodowym Centrum Nauki
ID : UMO-2017/25/B/NZ7/01290
Organisme : Narodowym Centrum Nauki
ID : UMO-2017/25/B/NZ7/01290
Informations de copyright
© 2023. The Author(s).
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