Promiscuous Yet Specific: A Methionine-Aromatic Interaction Drives the Reaction Scope of the Family 1 Glycosyltransferase

Glycosyltransferases / metabolism Glycine max / genetics Methionine / metabolism Glycosylation Glycosides Racemethionine / metabolism Substrate Specificity

Journal

Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623

Informations de publication

Date de publication:
05 Dec 2023
Historique:
medline: 6 12 2023
pubmed: 27 11 2023
entrez: 27 11 2023
Statut: ppublish

Résumé

Family 1 glycosyltransferases (GT1s, UGTs) catalyze the regioselective glycosylation of natural products in a single step. We identified

Identifiants

DOI: 10.1021/acs.biochem.3c00494 PMID: 38009918
pubmed: 38009918
doi: 10.1021/acs.biochem.3c00494
doi:

Substances chimiques

Glycosyltransferases EC 2.4.-
Methionine AE28F7PNPL
Glycosides 0
Racemethionine 73JWT2K6T3

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3343-3346

Auteurs

Ruben M de Boer (RM)

The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK- 2800 Kongens Lyngby, Denmark.
ORCID: 0000-0002-2239-7286

Dan E H Hvid (DE)

The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK- 2800 Kongens Lyngby, Denmark.
Department of Chemistry, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.

Elisa Davail (E)

The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK- 2800 Kongens Lyngby, Denmark.

Dovydas Vaitkus (D)

The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK- 2800 Kongens Lyngby, Denmark.

Jens Ø Duus (JØ)

Department of Chemistry, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.
ORCID: 0000-0003-3625-1250

Ditte H Welner (DH)

The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK- 2800 Kongens Lyngby, Denmark.
ORCID: 0000-0001-9297-4133

David Teze (D)

The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK- 2800 Kongens Lyngby, Denmark.
ORCID: 0000-0002-6865-6108

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Promiscuous Yet Specific: A...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Méthionine › Promiscuous Yet Specific: A...
questionsmedicales.fr › Métabolisme › Métabolisme glucidique › Glycosylation › Promiscuous Yet Specific: A...
questionsmedicales.fr › Glucides › Hétérosides › Promiscuous Yet Specific: A...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Méthionine › Racéméthionine › Promiscuous Yet Specific: A...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Spécificité du substrat › Promiscuous Yet Specific: A...