A papain-like cysteine protease-released small signal peptide confers wheat resistance to wheat yellow mosaic virus.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
27 Nov 2023
27 Nov 2023
Historique:
received:
02
07
2022
accepted:
15
11
2023
medline:
29
11
2023
pubmed:
28
11
2023
entrez:
27
11
2023
Statut:
epublish
Résumé
Wheat yellow mosaic virus (WYMV), a soil-borne pathogen, poses a serious threat to global wheat production. Here, we identify a WYMV resistance gene, TaRD21A, that belongs to the papain-like cysteine protease family. Through genetic manipulation of TaRD21A expression, we establish its positive role in the regulation of wheat to WYMV resistance. Furthermore, our investigation shows that the TaRD21A-mediated plant antiviral response relies on the release of a small peptide catalyzed by TaRD21A protease activity. To counteract wheat resistance, WYMV-encoded nuclear inclusion protease-a (NIa) suppress TaRD21A activity to promote virus infection. In resistant cultivars, a natural variant of TaRD21A features a glycine-to-threonine substitution and this substitution enables the phosphorylation of threonine, thereby weakening the interaction between NIa and TaRD21A, reinforcing wheat resistance against WYMV. Our study not only unveils a WYMV resistance gene but also offers insights into the intricate mechanisms underpinning resistance against WYMV.
Identifiants
pubmed: 38012219
doi: 10.1038/s41467-023-43643-y
pii: 10.1038/s41467-023-43643-y
pmc: PMC10682394
doi:
Substances chimiques
Papain
EC 3.4.22.2
Protein Sorting Signals
0
Threonine
2ZD004190S
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7773Subventions
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 32100126
Informations de copyright
© 2023. The Author(s).
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