Natural killer cells in the central nervous system.
Aging
Central nervous system
Multiple sclerosis
NK cells
Neurodegenerative diseases
Journal
Cell communication and signaling : CCS
ISSN: 1478-811X
Titre abrégé: Cell Commun Signal
Pays: England
ID NLM: 101170464
Informations de publication
Date de publication:
29 Nov 2023
29 Nov 2023
Historique:
received:
18
07
2023
accepted:
17
09
2023
medline:
1
12
2023
pubmed:
30
11
2023
entrez:
29
11
2023
Statut:
epublish
Résumé
Natural killer (NK) cells are essential components of the innate lymphoid cell family that work as both cytotoxic effectors and immune regulators. Accumulating evidence points to interactions between NK cells and the central nervous system (CNS). Here, we review the basic knowledge of NK cell biology and recent advances in their roles in the healthy CNS and pathological conditions, with a focus on normal aging, CNS autoimmune diseases, neurodegenerative diseases, cerebrovascular diseases, and CNS infections. We highlight the crosstalk between NK cells and diverse cell types in the CNS and the potential value of NK cells as novel therapeutic targets for CNS diseases. Video Abstract.
Identifiants
pubmed: 38031097
doi: 10.1186/s12964-023-01324-9
pii: 10.1186/s12964-023-01324-9
pmc: PMC10685650
doi:
Types de publication
Video-Audio Media
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
341Subventions
Organisme : National Natural Science Foundation of China
ID : No. 81925031, 81820108026
Organisme : Guangzhou Science and Technology Program key projects
ID : 202007030001
Informations de copyright
© 2023. The Author(s).
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