Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
06 Dec 2023
06 Dec 2023
Historique:
received:
09
02
2023
accepted:
22
11
2023
medline:
11
12
2023
pubmed:
7
12
2023
entrez:
6
12
2023
Statut:
epublish
Résumé
In high-income countries, mosaic chromosomal alterations in peripheral blood leukocytes are associated with an elevated risk of adverse health outcomes, including hematologic malignancies. We investigate mosaic chromosomal alterations in sub-Saharan Africa among 931 children with Burkitt lymphoma, an aggressive lymphoma commonly characterized by immunoglobulin-MYC chromosomal rearrangements, 3822 Burkitt lymphoma-free children, and 674 cancer-free men from Ghana. We find autosomal and X chromosome mosaic chromosomal alterations in 3.4% and 1.7% of Burkitt lymphoma-free children, and 8.4% and 3.7% of children with Burkitt lymphoma (P-values = 5.7×10
Identifiants
pubmed: 38057307
doi: 10.1038/s41467-023-43881-0
pii: 10.1038/s41467-023-43881-0
pmc: PMC10700489
doi:
Substances chimiques
Immunoglobulins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8081Subventions
Organisme : NHLBI NIH HHS
ID : HHSN261201100007C
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201100007I
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201100063C
Pays : United States
Informations de copyright
© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
Références
Leukemia. 2021 Apr;35(4):1209-1213
pubmed: 33051549
Hum Mutat. 2022 Dec;43(12):1979-1993
pubmed: 36054329
Blood. 2018 Feb 1;131(5):496-504
pubmed: 29141946
Am J Hum Genet. 2015 Mar 5;96(3):487-97
pubmed: 25748358
Nat Commun. 2019 Mar 29;10(1):1459
pubmed: 30926794
Am J Med. 1989 Aug;87(2):139-43
pubmed: 2667356
Nature. 2017 Oct 11;550(7675):244-248
pubmed: 29022598
Blood. 2006 Apr 1;107(7):2928-35
pubmed: 16332968
Nat Genet. 2012 May 06;44(6):642-50
pubmed: 22561516
Leukemia. 2022 Jul;36(7):1720-1748
pubmed: 35732829
Cell Death Dis. 2022 Oct 22;13(10):892
pubmed: 36270981
J Infect Dis. 2006 Feb 1;193(3):422-6
pubmed: 16388490
Sci Rep. 2021 Jan 13;11(1):1193
pubmed: 33441948
Genome Med. 2019 Apr 30;11(1):27
pubmed: 31039827
Science. 2015 Jun 5;348(6239):aaa0698
pubmed: 26045439
Bioinformatics. 2014 May 15;30(10):1363-9
pubmed: 24478339
Eur J Cancer (1965). 1981 May;17(5):577-84
pubmed: 6271555
Nat Genet. 2012 Dec;44(12):1316-20
pubmed: 23143595
Hum Mol Genet. 2015 May 15;24(10):2733-45
pubmed: 25634561
Am J Hum Genet. 2010 Jul 9;87(1):129-38
pubmed: 20598279
Matern Child Health J. 2015 Mar;19(3):606-14
pubmed: 24951129
Nat Rev Genet. 2002 Oct;3(10):748-58
pubmed: 12360233
Lancet. 1964 Mar 28;1(7335):702-3
pubmed: 14107961
Blood. 2002 Apr 15;99(8):2662-9
pubmed: 11929751
Semin Hematol. 2013 Oct;50(4):348-59
pubmed: 24246702
Nat Rev Immunol. 2015 Mar;15(3):172-84
pubmed: 25712152
Nat Genet. 2012 Dec;44(12):1321-5
pubmed: 23143597
Haematologica. 2010 Dec;95(12):2047-55
pubmed: 20823134
Nat Rev Dis Primers. 2022 Dec 15;8(1):78
pubmed: 36522349
Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2211055120
pubmed: 36595676
Nat Genet. 2015 Nov;47(11):1316-1325
pubmed: 26437030
Leukemia. 2021 Jul;35(7):2002-2016
pubmed: 33953289
Nat Med. 2021 Jun;27(6):1012-1024
pubmed: 34099924
Blood. 2023 Feb 23;141(8):904-916
pubmed: 36201743
Ann Hematol. 2002 Aug;81(8):441-7
pubmed: 12224001
Nature. 2022 Jul;607(7918):366-373
pubmed: 35705809
Br J Haematol. 2008 Mar;140(5):516-26
pubmed: 18275429
Int J Cancer. 2020 Feb 15;146(4):953-969
pubmed: 31054214
J Mol Diagn. 2006 May;8(2):141-51
pubmed: 16645199
Cancer Res. 2019 Jun 15;79(12):3125-3138
pubmed: 31000522
PLoS Genet. 2019 Mar 8;15(3):e1008027
pubmed: 30849090
Sci Rep. 2014 Jan 17;4:3741
pubmed: 24434689
Nature. 2012 Oct 4;490(7418):116-20
pubmed: 22885699
Nat Genet. 2009 May;41(5):521-3
pubmed: 19330029
Nat Biotechnol. 2015 Mar;33(3):290-5
pubmed: 25690850
Infect Agent Cancer. 2021 Jun 7;16(1):40
pubmed: 34099001
PLoS Pathog. 2015 Oct 15;11(10):e1005158
pubmed: 26468873
Br J Haematol. 2018 Jun;181(5):604-613
pubmed: 29687880
Mol Cancer Res. 2017 May;15(5):563-576
pubmed: 28465297
J Urol. 2014 Sep;192(3):730-5
pubmed: 24747091
J Genet Genomics. 2017 Feb 20;44(2):119-121
pubmed: 28162959
N Engl J Med. 2006 Jun 8;354(23):2419-30
pubmed: 16760442
Int J Cancer. 1985 Apr 15;35(4):435-41
pubmed: 2985508
Nat Genet. 2016 May;48(5):563-8
pubmed: 27064253
Blood. 2019 Mar 21;133(12):1313-1324
pubmed: 30617194
J Infect Dis. 2016 Mar 15;213(6):985-91
pubmed: 26531246
Nat Commun. 2016 Jun 13;7:11843
pubmed: 27291797
BMC Cancer. 2014 Dec 13;14:944
pubmed: 25495526
Nat Genet. 2012 May 06;44(6):651-8
pubmed: 22561519
Cell. 1999 Jan 8;96(1):35-45
pubmed: 9989495
Cancers (Basel). 2022 Jun 04;14(11):
pubmed: 35681780
RNA. 2021 Dec;27(12):1577-1588
pubmed: 34535544
Nature. 2018 Jul;559(7714):350-355
pubmed: 29995854
Cell Genom. 2023 May 02;3(6):100305
pubmed: 37388907
J Natl Cancer Inst. 1969 Jan;42(1):19-28
pubmed: 4303830
Nat Rev Genet. 2021 Aug;22(8):502-517
pubmed: 33833443