An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis.

Animals Humans Mice B7-H1 Antigen / antagonists & inhibitors Bone Marrow / drug effects Carcinogenesis / drug effects Carcinoma, Non-Small-Cell Lung / immunology CD8-Positive T-Lymphocytes / drug effects Immune Checkpoint Inhibitors / immunology Interleukin-4 / metabolism Lung Neoplasms / immunology Lymphocytes, Tumor-Infiltrating / drug effects Monocytes / drug effects Myelopoiesis Programmed Cell Death 1 Receptor / antagonists & inhibitors Recurrence Signal Transduction / drug effects

Journal

Nature

ISSN: 1476-4687

Titre abrégé: Nature

Pays: England

ID NLM: 0410462

Informations de publication

Date de publication:
Jan 2024

Historique:

received: 10 03 2023

accepted: 30 10 2023

medline: 5 1 2024

pubmed: 7 12 2023

entrez: 6 12 2023

Statut: ppublish

Résumé

Myeloid cells are known to suppress antitumour immunity

Identifiants

DOI: 10.1038/s41586-023-06797-9 PMID: 38057662

pubmed: 38057662

doi: 10.1038/s41586-023-06797-9

pii: 10.1038/s41586-023-06797-9

doi:

Substances chimiques

B7-H1 Antigen 0

dupilumab 420K487FSG

IL4 protein, human 0

Il4 protein, mouse 0

Il4ra protein, mouse 0

Immune Checkpoint Inhibitors 0

Interleukin-4 207137-56-2

Programmed Cell Death 1 Receptor 0

Banques de données

ClinicalTrials.gov

['NCT05013450']

Types de publication

Clinical Trial Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

166-174

Subventions

Organisme : NCI NIH HHS

ID : K00 CA223043

Pays : United States

Informations de copyright

Références

Barry, S. T., Gabrilovich, D. I., Sansom, O. J., Campbell, A. D. & Morton, J. P. Therapeutic targeting of tumour myeloid cells. Nat. Rev. Cancer 23, 216–237 (2023).

pubmed: 36747021 doi: 10.1038/s41568-022-00546-2

Castro, M. et al. Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma. N. Engl. J. Med. 378, 2486–2496 (2018).

pubmed: 29782217 doi: 10.1056/NEJMoa1804092

Rabe, K. F. et al. Efficacy and safety of dupilumab in glucocorticoid-dependent severe asthma. N. Engl. J. Med. 378, 2475–2485 (2018).

pubmed: 29782224 doi: 10.1056/NEJMoa1804093

Simpson, E. L. et al. Two phase 3 trials of dupilumab versus placebo in atopic dermatitis. N. Engl. J. Med. 375, 2335–2348 (2016).

pubmed: 27690741 doi: 10.1056/NEJMoa1610020

Beck, K. M., Yang, E. J., Sekhon, S., Bhutani, T. & Liao, W. Dupilumab treatment for generalized prurigo nodularis. JAMA Dermatol. 155, 118–120 (2019).

pubmed: 30427994 doi: 10.1001/jamadermatol.2018.3912

Herbst, R. S., Morgensztern, D. & Boshoff, C. The biology and management of non-small cell lung cancer. Nature 553, 446–454 (2018).

pubmed: 29364287 doi: 10.1038/nature25183

Lavin, Y. et al. Innate immune landscape in early lung adenocarcinoma by paired single-cell analyses. Cell 169, 750–765.e717 (2017).

pubmed: 28475900 pmcid: 5737939 doi: 10.1016/j.cell.2017.04.014

Leader, A. M. et al. Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification. Cancer Cell 39, 1594–1609.e1512 (2021).

pubmed: 34767762 pmcid: 8728963 doi: 10.1016/j.ccell.2021.10.009

Casanova-Acebes, M. et al. Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells. Nature 595, 578–584 (2021).

pubmed: 34135508 pmcid: 8923521 doi: 10.1038/s41586-021-03651-8

Loyher, P. L. et al. Macrophages of distinct origins contribute to tumor development in the lung. J. Exp. Med. 215, 2536–2553 (2018).

pubmed: 30201786 pmcid: 6170177 doi: 10.1084/jem.20180534

Maier, B. et al. A conserved dendritic-cell regulatory program limits antitumour immunity. Nature 580, 257–262 (2020).

pubmed: 32269339 pmcid: 7787191 doi: 10.1038/s41586-020-2134-y

Park, M. D. et al. TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer. Nat. Immunol. 24, 792–801 (2023).

pubmed: 37081148 doi: 10.1038/s41590-023-01475-4

Loschko, J. et al. Absence of MHC class II on cDCs results in microbial-dependent intestinal inflammation. J. Exp. Med. 213, 517–534 (2016).

pubmed: 27001748 pmcid: 4821651 doi: 10.1084/jem.20160062

Karasawa, K. et al. Vascular-resident CD169-positive monocytes and macrophages control neutrophil accumulation in the kidney with ischemia-reperfusion injury. J. Am. Soc. Nephrol. 26, 896–906 (2015).

pubmed: 25266072 doi: 10.1681/ASN.2014020195

Lee, P. P. et al. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 15, 763–774 (2001).

pubmed: 11728338 doi: 10.1016/S1074-7613(01)00227-8

Liu, Z. et al. Fate mapping via Ms4a3-expression history traces monocyte-derived cells. Cell 178, 1509–1525 e1519 (2019).

pubmed: 31491389 doi: 10.1016/j.cell.2019.08.009

Horton, B. L. et al. Lack of CD8

pubmed: 34714687 doi: 10.1126/sciimmunol.abi8800

Burger, M. L. et al. Antigen dominance hierarchies shape TCF1

pubmed: 34534464 pmcid: 8522630 doi: 10.1016/j.cell.2021.08.020

Chihara, N. et al. Induction and transcriptional regulation of the co-inhibitory gene module in T cells. Nature 558, 454–459 (2018).

pubmed: 29899446 pmcid: 6130914 doi: 10.1038/s41586-018-0206-z

Khan, O. et al. TOX transcriptionally and epigenetically programs CD8

pubmed: 31207603 pmcid: 6713202 doi: 10.1038/s41586-019-1325-x

Naluyima, P. et al. Terminal effector CD8 T cells defined by an IKZF2

pubmed: 31519862 pmcid: 6778306 doi: 10.4049/jimmunol.1900422

Akimova, T., Beier, U. H., Wang, L., Levine, M. H. & Hancock, W. W. Helios expression is a marker of T cell activation and proliferation. PLoS ONE 6, e24226 (2011).

pubmed: 21918685 pmcid: 3168881 doi: 10.1371/journal.pone.0024226

Thome, M. Multifunctional roles for MALT1 in T-cell activation. Nat. Rev. Immunol. 8, 495–500 (2008).

pubmed: 18575460 doi: 10.1038/nri2338

Yona, S. et al. Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity 38, 79–91 (2013).

pubmed: 23273845 doi: 10.1016/j.immuni.2012.12.001

Passegue, E., Wagner, E. F. & Weissman, I. L. JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Cell 119, 431–443 (2004).

pubmed: 15507213 doi: 10.1016/j.cell.2004.10.010

Abram, C. L., Roberge, G. L., Hu, Y. & Lowell, C. A. Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice. J. Immunol. Methods 408, 89–100 (2014).

pubmed: 24857755 pmcid: 4105345 doi: 10.1016/j.jim.2014.05.009

Mohrs, M., Shinkai, K., Mohrs, K. & Locksley, R. M. Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter. Immunity 15, 303–311 (2001).

pubmed: 11520464 doi: 10.1016/S1074-7613(01)00186-8

Hanna, R. N. et al. The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C

pubmed: 21725321 pmcid: 3324395 doi: 10.1038/ni.2063

Kurotaki, D. et al. Transcription factor IRF8 governs enhancer landscape dynamics in mononuclear phagocyte progenitors. Cell Rep. 22, 2628–2641 (2018).

pubmed: 29514092 doi: 10.1016/j.celrep.2018.02.048

Zhao, F. et al. S100A9 a new marker for monocytic human myeloid-derived suppressor cells. Immunology 136, 176–183 (2012).

pubmed: 22304731 pmcid: 3403264 doi: 10.1111/j.1365-2567.2012.03566.x

Hegde, S., Leader, A. M. & Merad, M. MDSC: markers, development, states, and unaddressed complexity. Immunity 54, 875–884 (2021).

pubmed: 33979585 pmcid: 8709560 doi: 10.1016/j.immuni.2021.04.004

Seita, J. & Weissman, I. L. Hematopoietic stem cell: self-renewal versus differentiation. Wiley Interdiscip. Rev. Syst. Biol. Med. 2, 640–653 (2010).

pubmed: 20890962 pmcid: 2950323 doi: 10.1002/wsbm.86

Yanez, A. et al. Granulocyte-monocyte progenitors and monocyte-dendritic cell progenitors independently produce functionally distinct monocytes. Immunity 47, 890–902 e894 (2017).

pubmed: 29166589 pmcid: 5726802 doi: 10.1016/j.immuni.2017.10.021

Mastio, J. et al. Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs. J. Exp. Med. 216, 2150–2169 (2019).

pubmed: 31239386 pmcid: 6719429 doi: 10.1084/jem.20181952

Nelms, K., Keegan, A. D., Zamorano, J., Ryan, J. J. & Paul, W. E. The IL-4 receptor: signaling mechanisms and biologic functions. Annu. Rev. Immunol. 17, 701–738 (1999).

pubmed: 10358772 doi: 10.1146/annurev.immunol.17.1.701

Jenkins, S. J. et al. Local macrophage proliferation, rather than recruitment from the blood, is a signature of T

pubmed: 21566158 pmcid: 3128495 doi: 10.1126/science.1204351

Paul, F. et al. Transcriptional heterogeneity and lineage commitment in myeloid progenitors. Cell 163, 1663–1677 (2015).

pubmed: 26627738 doi: 10.1016/j.cell.2015.11.013

Kwok, I. et al. Combinatorial single-cell analyses of granulocyte-monocyte progenitor heterogeneity reveals an early uni-potent neutrophil progenitor. Immunity 53, 303–318.e305 (2020).

pubmed: 32579887 doi: 10.1016/j.immuni.2020.06.005

Olsson, A. et al. Single-cell analysis of mixed-lineage states leading to a binary cell fate choice. Nature 537, 698–702 (2016).

pubmed: 27580035 pmcid: 5161694 doi: 10.1038/nature19348

Anderson, K. G. et al. Intravascular staining for discrimination of vascular and tissue leukocytes. Nat. Protoc. 9, 209–222 (2014).

pubmed: 24385150 pmcid: 4428344 doi: 10.1038/nprot.2014.005

Tsutsui, H. et al. The basophil-specific protease mMCP-8 provokes an inflammatory response in the skin with microvascular hyperpermeability and leukocyte infiltration. J. Biol. Chem. 292, 1061–1067 (2017).

pubmed: 27932459 doi: 10.1074/jbc.M116.754648

Cohen, M. et al. Lung single-cell signaling interaction map reveals basophil role in macrophage imprinting. Cell 175, 1031–1044.e1018 (2018).

pubmed: 30318149 doi: 10.1016/j.cell.2018.09.009

Obata, K. et al. Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood 110, 913–920 (2007).

pubmed: 17409268 doi: 10.1182/blood-2007-01-068718

Schultze, J. L., Mass, E. & Schlitzer, A. Emerging principles in myelopoiesis at homeostasis and during infection and inflammation. Immunity 50, 288–301 (2019).

pubmed: 30784577 doi: 10.1016/j.immuni.2019.01.019

Veglia, F., Sanseviero, E. & Gabrilovich, D. I. Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity. Nat. Rev. Immunol. 21, 485–498 (2021).

pubmed: 33526920 pmcid: 7849958 doi: 10.1038/s41577-020-00490-y

Pellefigues, C. et al. Diverse innate stimuli activate basophils through pathways involving Syk and IkappaB kinases. Proc. Natl Acad. Sci. USA 118, e2019524118 (2021).

pubmed: 33727419 pmcid: 8000355 doi: 10.1073/pnas.2019524118

Gandhi, L. et al. Pembrolizumab plus chemotherapy in metastatic non-small-cell lung cancer. N. Engl. J. Med. 378, 2078–2092 (2018).

pubmed: 29658856 doi: 10.1056/NEJMoa1801005

Spigel, D. R. et al. Five-year survival outcomes from the PACIFIC trial: durvalumab after chemoradiotherapy in stage III non-small-cell lung cancer. J. Clin. Oncol. 40, 1301–1311 (2022).

pubmed: 35108059 pmcid: 9015199 doi: 10.1200/JCO.21.01308

Herbst, R. S. et al. Five year survival update from KEYNOTE-010: pembrolizumab versus docetaxel for previously treated, programmed death-ligand 1-positive advanced NSCLC. J. Thorac. Oncol. 16, 1718–1732 (2021).

pubmed: 34048946 doi: 10.1016/j.jtho.2021.05.001

Choi, H. et al. Transcriptome analysis of individual stromal cell populations identifies stroma–tumor crosstalk in mouse lung cancer model. Cell Rep. 10, 1187–1201 (2015).

pubmed: 25704820 doi: 10.1016/j.celrep.2015.01.040

Patil, N. S. et al. Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer. Cancer Cell 40, 289–300.e284 (2022).

pubmed: 35216676 doi: 10.1016/j.ccell.2022.02.002

Petitprez, F. et al. B cells are associated with survival and immunotherapy response in sarcoma. Nature 577, 556–560 (2020).

pubmed: 31942077 doi: 10.1038/s41586-019-1906-8

Eisenhauer, E. A. et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur. J. Cancer 45, 228–247 (2009).

pubmed: 19097774 doi: 10.1016/j.ejca.2008.10.026

Anderson, N. R., Minutolo, N. G., Gill, S. & Klichinsky, M. Macrophage-based approaches for cancer immunotherapy. Cancer Res. 81, 1201–1208 (2020).

pubmed: 33203697 doi: 10.1158/0008-5472.CAN-20-2990

Alam, A. et al. Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer. Cancer Cell 40, 153–167.e111 (2022).

pubmed: 35120601 pmcid: 8847236 doi: 10.1016/j.ccell.2022.01.003

DeNardo, D. G. et al. CD4

pubmed: 19647220 pmcid: 2778576 doi: 10.1016/j.ccr.2009.06.018

Remark, R. et al. In-depth tissue profiling using multiplexed immunohistochemical consecutive staining on single slide. Sci. Immunol. 1, aaf6925 (2016).

pubmed: 28783673 pmcid: 10152404 doi: 10.1126/sciimmunol.aaf6925

Wang, F. et al. A basophil–neuronal axis promotes itch. Cell 184, 422–440.e417 (2021).

pubmed: 33450207 pmcid: 7878015 doi: 10.1016/j.cell.2020.12.033

Chen, E. Y. et al. Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinformatics 14, 128 (2013).

pubmed: 23586463 pmcid: 3637064 doi: 10.1186/1471-2105-14-128

Zhou, Y. et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat. Commun. 10, 1523 (2019).

pubmed: 30944313 pmcid: 6447622 doi: 10.1038/s41467-019-09234-6