Dorsal hippocampus to nucleus accumbens projections drive reinforcement via activation of accumbal dynorphin neurons.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
29 Jan 2024
29 Jan 2024
Historique:
received:
02
08
2022
accepted:
04
01
2024
medline:
31
1
2024
pubmed:
30
1
2024
entrez:
29
1
2024
Statut:
epublish
Résumé
The hippocampus is pivotal in integrating emotional processing, learning, memory, and reward-related behaviors. The dorsal hippocampus (dHPC) is particularly crucial for episodic, spatial, and associative memory, and has been shown to be necessary for context- and cue-associated reward behaviors. The nucleus accumbens (NAc), a central structure in the mesolimbic reward pathway, integrates the salience of aversive and rewarding stimuli. Despite extensive research on dHPC→NAc direct projections, their sufficiency in driving reinforcement and reward-related behavior remains to be determined. Our study establishes that activating excitatory neurons in the dHPC is sufficient to induce reinforcing behaviors through its direct projections to the dorso-medial subregion of the NAc shell (dmNAcSh). Notably, dynorphin-containing neurons specifically contribute to dHPC-driven reinforcing behavior, even though both dmNAcSh dynorphin- and enkephalin-containing neurons are activated with dHPC stimulation. Our findings unveil a pathway governing reinforcement, advancing our understanding of the hippocampal circuity's role in reward-seeking behaviors.
Identifiants
pubmed: 38286800
doi: 10.1038/s41467-024-44836-9
pii: 10.1038/s41467-024-44836-9
pmc: PMC10825206
doi:
Substances chimiques
Dynorphins
74913-18-1
1,2-dihexadecyl-sn-glycero-3-phosphocholine
0
Phospholipid Ethers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
750Subventions
Organisme : NIDA NIH HHS
ID : R21 DA055047
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA045463
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA042499
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA054900
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA041781
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA058613
Pays : United States
Informations de copyright
© 2024. The Author(s).
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