Perioperative Levels of IL8 and IL18, but not IL6, are Associated with Nucleus Basalis Magnocellularis Atrophy Three Months after Surgery.
Acetylcholine
Atrophy
Interleukins
Neurodegeneration
Nucleus basalis magnocellularis (of Meynert)
Surgery
Journal
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
ISSN: 1557-1904
Titre abrégé: J Neuroimmune Pharmacol
Pays: United States
ID NLM: 101256586
Informations de publication
Date de publication:
14 Mar 2024
14 Mar 2024
Historique:
received:
26
03
2023
accepted:
18
02
2024
medline:
18
3
2024
pubmed:
14
3
2024
entrez:
14
3
2024
Statut:
epublish
Résumé
Past studies have observed that brain atrophy may accelerate after surgical procedures. Furthermore, an association of systemic inflammation with neurodegeneration has been described. We hypothesize that postoperative interleukin (IL) levels in circulation as well as the perioperative change in interleukin levels are associated with increased postoperative atrophy in the Nucleus basalis magnocellularis (of Meynert, NBM) which is the major source of cortical acetylcholine. We analyzed data from the BioCog cohort which included patients ≥ 65 years presenting for elective major surgery (≥ 60min). Blood samples were taken before surgery and on the first postoperative day. Magnetic resonance imaging of the brain and neuropsychological assessments were conducted before surgery and after three months follow-up. We used linear regression analysis to determine the association of three interleukins (IL6, IL8 and IL18) with NBM atrophy (in % volume change from baseline before surgery to follow-up), as well as to examine the associations of NBM atrophy and volume with postoperative cognitive ability and perioperative cognitive change. Receiver-operating curves were used to determine the prognostic value of preoperative interleukin levels. For IL8 (N = 97) and IL18 (N = 217), but not IL6 (N = 240), we observed significant associations of higher postoperative IL levels at the first postoperative day with higher NBM atrophy at three months after surgery. Subsequent analyses suggested that in both IL8 and IL18, this association was driven by a more general association of chronically elevated IL levels and NBM atrophy, reflected by preoperative IL concentrations, rather than IL response to surgery, measured as the difference between pre- and postoperative IL concentrations. At follow-up, NBM volume was positively associated with the level of cognitive performance, but NBM atrophy was not significantly related to perioperative cognitive change. Prognostic value of preoperative IL concentrations for NBM atrophy was low. Our results suggest that an association of postoperative interleukin levels with NBM atrophy is driven by preoperatively elevated interleukins due to pre-existing inflammation, rather than perioperative change in interleukin levels in response to surgery and anesthesia. The BioCog study has been registered at clinicaltrials.gov on Oct 15, 2014 (NCT02265263).
Identifiants
pubmed: 38483732
doi: 10.1007/s11481-024-10110-4
pii: 10.1007/s11481-024-10110-4
pmc: PMC10940494
doi:
Substances chimiques
Interleukin-18
0
Interleukin-8
0
Banques de données
ClinicalTrials.gov
['NCT02265263']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
10Subventions
Organisme : Berlin Institute of Health
ID : Digital Clinician Scientist Program
Organisme : European Commission
ID : 602461
Organisme : European Commission
ID : 602461
Organisme : European Commission
ID : 602461
Organisme : European Commission
ID : 602461
Informations de copyright
© 2024. The Author(s).
Références
Neurobiol Aging. 2013 Apr;34(4):1210-20
pubmed: 23158764
Med Sci Monit. 2016 Nov 22;22:4503-4508
pubmed: 27872469
Cortex. 2016 Oct;83:124-35
pubmed: 27509365
Inflamm Cell Signal. 2014;1(1):
pubmed: 26052539
J Neurochem. 1999 May;72(5):2215-8
pubmed: 10217305
Neurosci Lett. 1994 Sep 26;179(1-2):53-6
pubmed: 7845624
Cereb Cortex. 2017 Mar 1;27(3):1841-1848
pubmed: 26879092
Ann Rheum Dis. 2018 Jun;77(6):840-847
pubmed: 29472362
Brain Behav Immun. 2017 Oct;65:150-160
pubmed: 28457809
Neuropsychopharmacology. 2021 Dec;46(13):2320-2329
pubmed: 34188186
Neurobiol Aging. 2009 Feb;30(2):198-209
pubmed: 17658666
Neuropathology. 2006 Aug;26(4):307-12
pubmed: 16961066
Int J Mol Sci. 2019 Feb 02;20(3):
pubmed: 30717382
Acta Ophthalmol. 2013 Feb;91(1):58-65
pubmed: 22103594
Alzheimers Dement. 2016 May;12(5):590-7
pubmed: 26610898
J Gerontol A Biol Sci Med Sci. 2020 Nov 13;75(12):2239-2248
pubmed: 31900470
J Comp Neurol. 1983 Feb 20;214(2):170-97
pubmed: 6841683
Chest. 2004 Sep;126(3):926-34
pubmed: 15364775
Brain Res. 1985 Jul 15;338(2):337-40
pubmed: 4027599
Anesthesiology. 2012 Mar;116(3):603-12
pubmed: 22293721
J Neurosci Res. 1994 Oct 15;39(3):339-46
pubmed: 7869426
Neuropsychologia. 2018 Oct;119:145-156
pubmed: 30096414
J Alzheimers Dis. 2016 Jun 18;53(3):991-1001
pubmed: 27340852
Sci Rep. 2017 Sep 15;7(1):11706
pubmed: 28916821
Cytokine. 2015 Dec;76(2):433-441
pubmed: 26303011
Brain Behav Immun Health. 2022 Jan 21;20:100419
pubmed: 35141571
Brain Behav. 2015 Dec 29;6(1):e00421
pubmed: 27110442
Eur J Anaesthesiol. 2019 Feb;36(2):114-122
pubmed: 30431498
Brain Commun. 2023 Jan 30;5(1):fcad013
pubmed: 36819940
J Gerontol A Biol Sci Med Sci. 2021 May 22;76(6):1029-1036
pubmed: 32710543
PLoS One. 2016 Mar 01;11(3):e0150018
pubmed: 26930607
Brain. 2018 Jul 1;141(7):1917-1933
pubmed: 29850777
Brain Imaging Behav. 2022 Feb;16(1):118-129
pubmed: 34176042
Brain Res Rev. 2011 Jun 24;67(1-2):157-83
pubmed: 21238488
Brain. 2016 Apr;139(Pt 4):1282-94
pubmed: 26920674
Psychogeriatrics. 2019 Jul;19(4):300-309
pubmed: 30790387
J Immunother Cancer. 2019 Sep 5;7(1):240
pubmed: 31488216
Brain Res Mol Brain Res. 1999 Apr 6;67(1):46-52
pubmed: 10101231
Brain Res. 1984 Oct 8;311(1):194-8
pubmed: 6488042
Neurobiol Aging. 2008 Jun;29(6):937-44
pubmed: 17207897
BMC Res Notes. 2020 Feb 4;13(1):55
pubmed: 32019577
Front Hum Neurosci. 2019 Aug 27;13:290
pubmed: 31507395
BMC Anesthesiol. 2022 Sep 16;22(1):293
pubmed: 36114455
J Neurosci. 2012 May 2;32(18):6288-94
pubmed: 22553034
Brain Res Mol Brain Res. 2000 May 5;77(2):290-3
pubmed: 10837926
Neuroimage Clin. 2013 Oct 06;3:388-95
pubmed: 24273722
Neuroimage. 2008 Sep 1;42(3):1127-41
pubmed: 18585468
Eur Psychiatry. 2018 Apr;50:34-39
pubmed: 29398565
Transl Neurosci. 2014 Mar;5(1):1-7
pubmed: 27066268
Brain Res. 1987 May 19;411(2):332-40
pubmed: 3607437
Neuroscience. 2018 Dec 15;395:22-34
pubmed: 30326289
PLoS One. 2018 Jul 11;13(7):e0196636
pubmed: 29995884
Acta Anaesthesiol Scand. 2019 Nov;63(10):1282-1289
pubmed: 31283835
BMC Med Genomics. 2021 Oct 21;14(1):248
pubmed: 34674705
Pediatr Neurol. 2005 Aug;33(2):105-9
pubmed: 16087054
Dement Geriatr Cogn Disord. 2003;16(3):136-44
pubmed: 12826739
Neurobiol Aging. 2018 May;65:201-205
pubmed: 29499501
Brain. 2019 Jan 1;143(1):47-54
pubmed: 31802104
Br J Anaesth. 2019 Dec;123(6):808-817
pubmed: 31587833
J Gerontol A Biol Sci Med Sci. 2022 Dec 29;77(12):2464-2473
pubmed: 35040961
Br J Anaesth. 2021 Feb;126(2):458-466
pubmed: 33228978
J Alzheimers Dis. 2020;75(1):187-199
pubmed: 32250290
Int J Clin Pharmacol Ther. 2014 Oct;52(10):867-79
pubmed: 25109413
Int J Anesthesiol Res. 2016 Aug;4(8):313-321
pubmed: 28317003
Am J Respir Cell Mol Biol. 1990 Jun;2(6):479-86
pubmed: 2189453