New imidazole-2-thiones linked to acenaphythylenone as dual DNA intercalators and topoisomerase II inhibitors: structural optimization, docking, and apoptosis studies.

Topoisomerase II Inhibitors / pharmacology Structure-Activity Relationship Intercalating Agents / pharmacology Thiones / pharmacology Antineoplastic Agents / pharmacology Cell Line, Tumor Imidazoles / pharmacology DNA Apoptosis Molecular Docking Simulation DNA Topoisomerases, Type II / metabolism Cell Proliferation
DNA intercalators New imidazole-2-thiones doxorubicin dual anticancer activity topoisomerase II inhibitor

Journal

Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203

Informations de publication

Date de publication:
Dec 2024
Historique:
medline: 18 3 2024
pubmed: 15 3 2024
entrez: 15 3 2024
Statut: ppublish

Résumé

In this article, a new series of 2-((3,5-disubstituted-2-thioxo-imidazol-1-yl)imino)acenaphthylen-1(2

Identifiants

DOI: 10.1080/14756366.2024.2311818 PMID: 38488131
pubmed: 38488131
doi: 10.1080/14756366.2024.2311818
doi:

Substances chimiques

Topoisomerase II Inhibitors 0
imidazole 7GBN705NH1
Intercalating Agents 0
Thiones 0
Antineoplastic Agents 0
Imidazoles 0
DNA 9007-49-2
DNA Topoisomerases, Type II EC 5.99.1.3

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2311818

Auteurs

Asmaa H Mohamed (AH)

Chemistry Department, Faculty of Science, Minia University, El-Minia, Egypt.

Mohammed B Alshammari (MB)

Chemistry Department, College of Sciences and Humanities, Prince Sattam Bin Abdulaziz University, Al-Kharij, Saudi Arabia.
ORCID: 0000-0001-9687-8747

Ashraf A Aly (AA)

Chemistry Department, Faculty of Science, Minia University, El-Minia, Egypt.
ORCID: 0000-0002-0314-3408

Kamal U Sadek (KU)

Chemistry Department, Faculty of Science, Minia University, El-Minia, Egypt.

Akil Ahmad (A)

Chemistry Department, College of Sciences and Humanities, Prince Sattam Bin Abdulaziz University, Al-Kharij, Saudi Arabia.

Eman A Aziz (EA)

Chemistry Department, Faculty of Science, Minia University, El-Minia, Egypt.

Amira F El-Yazbi (AF)

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

Eman J El-Agroudy (EJ)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
ORCID: 0000-0003-1947-1227

Marwa E Abdelaziz (ME)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
ORCID: 0000-0002-8936-8172

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Inhibiteurs des topoisomérases › Inhibiteurs de la topoisomérase-II › New imidazole-2-thiones linked to...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › New imidazole-2-thiones linked to...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Intercalants › New imidazole-2-thiones linked to...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Thiones › New imidazole-2-thiones linked to...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › New imidazole-2-thiones linked to...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › New imidazole-2-thiones linked to...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › New imidazole-2-thiones linked to...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › New imidazole-2-thiones linked to...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › New imidazole-2-thiones linked to...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › New imidazole-2-thiones linked to...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Isomerases › DNA topoisomerases › ADN topoisomérases de type II › New imidazole-2-thiones linked to...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › New imidazole-2-thiones linked to...