Native-lung complications following single-lung transplantation for interstitial lung disease: an in-depth analysis.
Humans
Lung Diseases, Interstitial
/ surgery
Lung Transplantation
/ adverse effects
Retrospective Studies
Female
Male
Middle Aged
Adult
Lung
/ diagnostic imaging
Postoperative Complications
/ etiology
Aged
Pneumothorax
/ etiology
Tomography, X-Ray Computed
Disease Progression
Pulmonary Aspergillosis
/ surgery
Survival Rate
Acute exacerbation
Aspergillus
Lung transplant
Native lung
Pneumothorax
Single lung transplant
Journal
BMC pulmonary medicine
ISSN: 1471-2466
Titre abrégé: BMC Pulm Med
Pays: England
ID NLM: 100968563
Informations de publication
Date de publication:
24 Apr 2024
24 Apr 2024
Historique:
received:
11
11
2023
accepted:
11
04
2024
medline:
25
4
2024
pubmed:
25
4
2024
entrez:
24
4
2024
Statut:
epublish
Résumé
Interstitial lung disease (ILD) represents a heterogeneous group of lung disorders characterized by fibrotic lung tissue changes. In regions with severe donor shortages, single-lung transplantation (SLTx) is often preferred over bilateral lung transplantation for advanced ILD. However, temporal changes and complications in the retained native lung remain poorly understood. A retrospective analysis of 149 recipients who had undergone SLTx was conducted, including 34 ILD SLTx recipients. Native-lung volume, radiological alterations, and perfusion were assessed at distinct post-SLTx time points. Statistical analyses compared ILD and non-ILD SLTx groups. Our study revealed a progressive reduction in native-lung volume over time, accompanied by radiographic deterioration and declining perfusion. Complications in the retained native lung were observed, such as pneumothorax (29.4%), pulmonary aspergillosis (11.8%), and acute exacerbation (8.9%). Long-term survival rates were similar between ILD and non-ILD SLTx recipients. This study illuminates the unique challenges and complications with respect to the native lung following SLTx for ILD. Ongoing monitoring and tailored management are essential. Despite limitations, this research contributes to our understanding of the temporal progression of native-lung complications post-SLTx for ILD, underscoring the need for further investigation.
Sections du résumé
BACKGROUND
BACKGROUND
Interstitial lung disease (ILD) represents a heterogeneous group of lung disorders characterized by fibrotic lung tissue changes. In regions with severe donor shortages, single-lung transplantation (SLTx) is often preferred over bilateral lung transplantation for advanced ILD. However, temporal changes and complications in the retained native lung remain poorly understood.
METHODS
METHODS
A retrospective analysis of 149 recipients who had undergone SLTx was conducted, including 34 ILD SLTx recipients. Native-lung volume, radiological alterations, and perfusion were assessed at distinct post-SLTx time points. Statistical analyses compared ILD and non-ILD SLTx groups.
RESULTS
RESULTS
Our study revealed a progressive reduction in native-lung volume over time, accompanied by radiographic deterioration and declining perfusion. Complications in the retained native lung were observed, such as pneumothorax (29.4%), pulmonary aspergillosis (11.8%), and acute exacerbation (8.9%). Long-term survival rates were similar between ILD and non-ILD SLTx recipients.
CONCLUSIONS
CONCLUSIONS
This study illuminates the unique challenges and complications with respect to the native lung following SLTx for ILD. Ongoing monitoring and tailored management are essential. Despite limitations, this research contributes to our understanding of the temporal progression of native-lung complications post-SLTx for ILD, underscoring the need for further investigation.
Identifiants
pubmed: 38658879
doi: 10.1186/s12890-024-03009-6
pii: 10.1186/s12890-024-03009-6
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
202Subventions
Organisme : Japan Society for the Promotion of Science
ID : 20K08509
Organisme : Takeda Science Foundation
ID : Visionary Research 2021
Organisme : Tokyo-Hokenkai Byotai-Seiri Laboratory
ID : Clinical Research Grant 2022
Organisme : Research Center at the Institute of Development, Aging and Cancer, Tohoku University
ID : 2023
Informations de copyright
© 2024. The Author(s).
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