The associations between maternal and fetal exposure to endocrine-disrupting chemicals and asymmetric fetal growth restriction: a prospective cohort study.
Humans
Female
Endocrine Disruptors
/ adverse effects
Prospective Studies
Pregnancy
Fetal Growth Retardation
/ chemically induced
Adult
Benzhydryl Compounds
/ adverse effects
Phenols
/ urine
Maternal Exposure
/ adverse effects
Fetal Blood
/ chemistry
Fluorocarbons
/ blood
Phthalic Acids
/ urine
Caprylates
/ blood
Placental Insufficiency
Republic of Korea
/ epidemiology
Seoul
/ epidemiology
bisphenol-A
endocrine disruptors
fetal growth restriction
monoethyl phthalates
perfluorooctanoic acid
placental insufficiency
Journal
Frontiers in public health
ISSN: 2296-2565
Titre abrégé: Front Public Health
Pays: Switzerland
ID NLM: 101616579
Informations de publication
Date de publication:
2024
2024
Historique:
received:
07
12
2023
accepted:
21
03
2024
medline:
26
4
2024
pubmed:
26
4
2024
entrez:
26
4
2024
Statut:
epublish
Résumé
Recent evidence has revealed associations between endocrine-disrupting chemicals (EDCs) and placental insufficiency due to altered placental growth, syncytialization, and trophoblast invasion. However, no epidemiologic study has reported associations between exposure to EDCs and asymmetric fetal growth restriction (FGR) caused by placenta insufficiency. The aim of this study was to evaluate the association between EDC exposure and asymmetric FGR. This was a prospective cohort study including women admitted for delivery to the Maternal Fetal Center at Seoul St. Mary's Hospital between October 2021 and October 2022. Maternal urine and cord blood samples were collected, and the levels of bisphenol-A (BPA), monoethyl phthalates, and perfluorooctanoic acid in each specimen were analyzed. We investigated linear and non-linear associations between the levels of EDCs and fetal growth parameters, including the head circumference (HC)/abdominal circumference (AC) ratio as an asymmetric parameter. The levels of EDCs were compared between fetuses with and without asymmetric FGR. Of the EDCs, only the fetal levels of BPA showed a linear association with the HC/AC ratio after adjusting for confounding variables (
Identifiants
pubmed: 38665245
doi: 10.3389/fpubh.2024.1351786
pmc: PMC11043493
doi:
Substances chimiques
Endocrine Disruptors
0
Benzhydryl Compounds
0
bisphenol A
MLT3645I99
Phenols
0
Fluorocarbons
0
Phthalic Acids
0
perfluorooctanoic acid
947VD76D3L
Caprylates
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1351786Informations de copyright
Copyright © 2024 Hong, Kang, Kim, Won, Kim, Wie, Shin, Choi, Jo, Kim, Yang, Kang, Lee, Park, Park and Ko.
Déclaration de conflit d'intérêts
MY and HWK were employed by the company Goodbeing Center Co. Ltd., Republic of Korea. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.