Neurosteroid Modulation of Synaptic and Extrasynaptic GABA

Animals Nucleus Accumbens / metabolism Mice Receptors, GABA-A / metabolism Neurosteroids / metabolism Pregnanolone / pharmacology Synapses / metabolism Mice, Inbred C57BL Female Male Synaptic Transmission / drug effects Neurons / metabolism
allopregnanolone brexanolone nucleus accumbens phasic inhibition tonic inhibition zuranolone GABAA receptor

Journal

Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414

Informations de publication

Date de publication:
09 Apr 2024
Historique:
received: 14 02 2024
revised: 29 03 2024
accepted: 04 04 2024
medline: 27 4 2024
pubmed: 27 4 2024
entrez: 27 4 2024
Statut: epublish

Résumé

The recent approval of formulations of the endogenous neurosteroid allopregnanolone (brexanolone) and the synthetic neuroactive steroid SAGE-217 (zuranolone) to treat postpartum depression (PPD) has encouraged further research to elucidate why these potent enhancers of GABA

Identifiants

DOI: 10.3390/biom14040460 PMID: 38672476
pubmed: 38672476
pii: biom14040460
doi: 10.3390/biom14040460
pii:
doi:

Substances chimiques

Receptors, GABA-A 0
Neurosteroids 0
Pregnanolone BXO86P3XXW

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Medical Research Council
ID : Studentship 1313951
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 221617/Z/20/Z
Pays : United Kingdom

Auteurs

Scott J Mitchell (SJ)

Division of Cellular & Systems Medicine, School of Medicine, Medical Sciences Institute, Dundee University, Dow Street, Dundee DD1 5HL, UK.
ORCID: 0000-0002-1232-2897

Grant D Phillips (GD)

Division of Cellular & Systems Medicine, School of Medicine, Medical Sciences Institute, Dundee University, Dow Street, Dundee DD1 5HL, UK.

Becks Tench (B)

Division of Cellular & Systems Medicine, School of Medicine, Medical Sciences Institute, Dundee University, Dow Street, Dundee DD1 5HL, UK.
ORCID: 0000-0003-3032-7306

Yunkai Li (Y)

Division of Cellular & Systems Medicine, School of Medicine, Medical Sciences Institute, Dundee University, Dow Street, Dundee DD1 5HL, UK.

Delia Belelli (D)

Division of Cellular & Systems Medicine, School of Medicine, Medical Sciences Institute, Dundee University, Dow Street, Dundee DD1 5HL, UK.

Stephen J Martin (SJ)

Division of Cellular & Systems Medicine, School of Medicine, Medical Sciences Institute, Dundee University, Dow Street, Dundee DD1 5HL, UK.
ORCID: 0000-0003-0805-8541

Jerome D Swinny (JD)

School of Pharmacy & Biomedical Sciences, St. Michael's Building, University of Portsmouth, White Swan Road, Portsmouth PO1 2DT, UK.

Louise Kelly (L)

School of Pharmacy & Biomedical Sciences, St. Michael's Building, University of Portsmouth, White Swan Road, Portsmouth PO1 2DT, UK.
ORCID: 0000-0002-5119-519X

John R Atack (JR)

Main Building, Medicines Discovery Institute, Park Place, Cardiff University, Cardiff, CF10 3AT, UK.

Michael Paradowski (M)

Main Building, Medicines Discovery Institute, Park Place, Cardiff University, Cardiff, CF10 3AT, UK.
ORCID: 0000-0003-3857-0116

Jeremy J Lambert (JJ)

Division of Cellular & Systems Medicine, School of Medicine, Medical Sciences Institute, Dundee University, Dow Street, Dundee DD1 5HL, UK.
ORCID: 0000-0002-4204-3602

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Neurosteroid Modulation of Synaptic and...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Striatum ventral › Noyau accumbens › Neurosteroid Modulation of Synaptic and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Neurosteroid Modulation of Synaptic and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › Récepteurs GABA-A › Neurosteroid Modulation of Synaptic and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Neurostéroïdes › Neurosteroid Modulation of Synaptic and...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Prégnanes › Prégnanolone › Neurosteroid Modulation of Synaptic and...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Neurosteroid Modulation of Synaptic and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Neurosteroid Modulation of Synaptic and...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Neurosteroid Modulation of Synaptic and...
questionsmedicales.fr › Cellules › Neurones › Neurosteroid Modulation of Synaptic and...