[Immune Regulation by TNF Receptor-associated Factor 5].
Humans
Animals
TNF Receptor-Associated Factor 5
/ genetics
Signal Transduction
CD4-Positive T-Lymphocytes
/ immunology
Encephalomyelitis, Autoimmune, Experimental
/ immunology
Cytokine Receptor gp130
/ physiology
Th17 Cells
/ immunology
Interleukin-6
/ metabolism
Cell Differentiation
Receptors, Interleukin-6
/ physiology
Janus Kinases
/ metabolism
STAT Transcription Factors
/ physiology
Mice
CD4 T cell
autoimmune disease
cytokine
glycoprotein 130
tumor necrosis factor receptor-associated factor
Journal
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
ISSN: 1347-5231
Titre abrégé: Yakugaku Zasshi
Pays: Japan
ID NLM: 0413613
Informations de publication
Date de publication:
2024
2024
Historique:
medline:
2
5
2024
pubmed:
2
5
2024
entrez:
1
5
2024
Statut:
ppublish
Résumé
The tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family of molecules are intracellular adaptors that regulate cellular signaling through members of the TNFR and Toll-like receptor superfamily. Mammals have seven TRAF molecules numbered sequentially from TRAF1 to TRAF7. Although TRAF5 was identified as a potential regulator of TNFR superfamily members, the in vivo function of TRAF5 has not yet been fully elucidated. We identified an unconventional role of TRAF5 in interleukin-6 (IL-6) receptor signaling involving CD4
Identifiants
pubmed: 38692922
doi: 10.1248/yakushi.23-00154-3
doi:
Substances chimiques
TNF Receptor-Associated Factor 5
0
Cytokine Receptor gp130
133483-10-0
Interleukin-6
0
Receptors, Interleukin-6
0
Janus Kinases
EC 2.7.10.2
STAT Transcription Factors
0
Types de publication
Journal Article
Review
English Abstract
Langues
jpn
Sous-ensembles de citation
IM