Receptor-interacting protein kinase-3 (RIPK3): a new biomarker for necrotising enterocolitis in preterm infants.
Humans
Enterocolitis, Necrotizing
/ blood
Infant, Newborn
Receptor-Interacting Protein Serine-Threonine Kinases
/ blood
Biomarkers
/ blood
Infant, Premature
Male
Female
C-Reactive Protein
/ metabolism
Prognosis
ROC Curve
Severity of Illness Index
Infant, Premature, Diseases
/ blood
Case-Control Studies
Lactic Acid
/ blood
Biomarker
Diagnostic value
Necrotising enterocolitis
Predictive value
Receptor-interacting protein kinase-3
Journal
Pediatric surgery international
ISSN: 1437-9813
Titre abrégé: Pediatr Surg Int
Pays: Germany
ID NLM: 8609169
Informations de publication
Date de publication:
02 May 2024
02 May 2024
Historique:
accepted:
13
04
2024
medline:
2
5
2024
pubmed:
2
5
2024
entrez:
2
5
2024
Statut:
epublish
Résumé
This study aimed to evaluate the role of receptor-interacting protein kinase-3 (RIPK3) in the diagnosis, estimation of disease severity, and prognosis of premature infants with necrotising enterocolitis (NEC). RIPK3, lactic acid (LA), and C-reactive protein (CRP) levels were measured in the peripheral blood of 108 premature infants between 2019 and 2023, including 24 with stage II NEC, 18 with stage III NEC and 66 controls. Diagnostic values of the indicators for NEC were evaluated via receiver operating characteristic (ROC) curve analysis. Plasma RIPK3 and LA levels upon NEC suspicion in neonates with stage III NEC were 32.37 ± 16.20 ng/mL. The ROC curve for the combination of RIPK3, LA, CRP for NEC diagnosis were 0.925. The time to full enteral feeding (FEFt) after recovery from NEC was different between two expression groups of plasma RIPK3 (RIPK3 < 20.06 ng/mL and RIPK3 ≥ 20.06 ng/mL). Plasma RIPK3 can be used as a promising marker for the diagnosis and estimation of disease severity of premature infants with NEC and for the guidance on proper feeding strategies after recovery from NEC.
Identifiants
pubmed: 38696138
doi: 10.1007/s00383-024-05697-x
pii: 10.1007/s00383-024-05697-x
doi:
Substances chimiques
Receptor-Interacting Protein Serine-Threonine Kinases
EC 2.7.11.1
Biomarkers
0
RIPK3 protein, human
EC 2.7.11.1
C-Reactive Protein
9007-41-4
Lactic Acid
33X04XA5AT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115Subventions
Organisme : the Science and Technology Project of Suzhou
ID : SYS2019095
Organisme : the Scientific Research Project of the Jiangsu Health Committee
ID : LGY2020045
Informations de copyright
© 2024. The Author(s).
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