Laboratory parameters related to disease severity and physical performance after reconvalescence of acute COVID-19 infection.
Humans
COVID-19
/ blood
Female
Male
Middle Aged
Severity of Illness Index
Biomarkers
/ blood
SARS-CoV-2
/ isolation & purification
Aged
Adult
Physical Functional Performance
Interleukin-6
/ blood
C-Reactive Protein
/ metabolism
Inflammation
Tryptophan
/ blood
Neopterin
/ blood
Phenylalanine
/ blood
Amino Acids
/ blood
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
06 May 2024
06 May 2024
Historique:
received:
28
09
2023
accepted:
18
03
2024
medline:
7
5
2024
pubmed:
7
5
2024
entrez:
6
5
2024
Statut:
epublish
Résumé
Research into the molecular basis of disease trajectory and Long-COVID is important to get insights toward underlying pathophysiological processes. The objective of this study was to investigate inflammation-mediated changes of metabolism in patients with acute COVID-19 infection and throughout a one-year follow up period. The study enrolled 34 patients with moderate to severe COVID-19 infection admitted to the University Clinic of Innsbruck in early 2020. The dynamics of multiple laboratory parameters (including inflammatory markers [C-reactive protein (CRP), interleukin-6 (IL-6), neopterin] as well as amino acids [tryptophan (Trp), phenylalanine (Phe) and tyrosine (Tyr)], and parameters of iron and vitamin B metabolism) was related to disease severity and patients' physical performance. Also, symptom load during acute illness and at approximately 60 days (FU1), and one year after symptom onset (FU2) were monitored and related with changes of the investigated laboratory parameters: During acute infection many investigated laboratory parameters were elevated (e.g., inflammatory markers, ferritin, kynurenine, phenylalanine) and enhanced tryptophan catabolism and phenylalanine accumulation were found. At FU2 nearly all laboratory markers had declined back to reference ranges. However, kynurenine/tryptophan ratio (Kyn/Trp) and the phenylalanine/tyrosine ratio (Phe/Tyr) were still exceeding the 95th percentile of healthy controls in about two thirds of our cohort at FU2. Lower tryptophan concentrations were associated with B vitamin availability (during acute infection and at FU1), patients with lower vitamin B12 levels at FU1 had a prolonged and more severe impairment of their physical functioning ability. Patients who had fully recovered (ECOG 0) presented with higher concentrations of iron parameters (ferritin, hepcidin, transferrin) and amino acids (phenylalanine, tyrosine) at FU2 compared to patients with restricted ability to work. Persistent symptoms at FU2 were tendentially associated with IFN-γ related parameters. Women were affected by long-term symptoms more frequently. Conclusively, inflammation-mediated biochemical changes appear to be related to symptoms of patients with acute and Long Covid.
Identifiants
pubmed: 38710760
doi: 10.1038/s41598-024-57448-6
pii: 10.1038/s41598-024-57448-6
doi:
Substances chimiques
Biomarkers
0
Interleukin-6
0
C-Reactive Protein
9007-41-4
Tryptophan
8DUH1N11BX
Neopterin
670-65-5
Phenylalanine
47E5O17Y3R
Amino Acids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10388Subventions
Organisme : TYROLEAN REGIONAL GOVERNMENT
ID : GZ 75759
Organisme : TYROLEAN REGIONAL GOVERNMENT
ID : GZ 75759
Organisme : TYROLEAN REGIONAL GOVERNMENT
ID : GZ 75759
Organisme : TYROLEAN REGIONAL GOVERNMENT
ID : GZ 75759
Organisme : TYROLEAN REGIONAL GOVERNMENT
ID : GZ 75759
Organisme : TYROLEAN REGIONAL GOVERNMENT
ID : GZ 75759
Organisme : TYROLEAN REGIONAL GOVERNMENT
ID : GZ 75759
Organisme : TYROLEAN REGIONAL GOVERNMENT
ID : GZ 75759
Organisme : TYROLEAN REGIONAL GOVERNMENT
ID : GZ 75759
Organisme : TYROLEAN REGIONAL GOVERNMENT
ID : GZ 75759
Organisme : TYROLEAN REGIONAL GOVERNMENT
ID : GZ 75759
Organisme : TYROLEAN REGIONAL GOVERNMENT
ID : GZ 75759
Organisme : TYROLEAN REGIONAL GOVERNMENT
ID : GZ 75759
Organisme : TYROLEAN REGIONAL GOVERNMENT
ID : GZ 75759
Organisme : TYROLEAN REGIONAL GOVERNMENT
ID : GZ 75759
Informations de copyright
© 2024. The Author(s).
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