Identification of Novel Peptides in Distillers' Grains as Antioxidants, α-Glucosidase Inhibitors, and Insulin Sensitizers: In Silico and In Vitro Evaluation.
Glycoside Hydrolase Inhibitors
/ pharmacology
Hep G2 Cells
Humans
Antioxidants
/ pharmacology
Insulin Resistance
Molecular Docking Simulation
Peptides
/ pharmacology
Edible Grain
alpha-Glucosidases
/ metabolism
Protein Hydrolysates
/ pharmacology
Reactive Oxygen Species
/ metabolism
Hypoglycemic Agents
/ pharmacology
Computer Simulation
Insulin
Sulfonic Acids
Biphenyl Compounds
Picrates
Benzothiazoles
UHPLC-ESI-HRMS/MS
bioactive peptides
insulin resistance
molecular docking
reactive oxygen species
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
25 Apr 2024
25 Apr 2024
Historique:
received:
14
03
2024
revised:
22
04
2024
accepted:
23
04
2024
medline:
11
5
2024
pubmed:
11
5
2024
entrez:
11
5
2024
Statut:
epublish
Résumé
Distillers' grains are rich in protein and constitute a high-quality source of various bioactive peptides. The purpose of this study is to identify novel bioactive peptides with α-glucosidase inhibitory, antioxidant, and insulin resistance-ameliorating effects from distiller's grains protein hydrolysate. Three novel peptides (YPLPR, AFEPLR, and NDPF) showed good potential bioactivities, and the YPLPR peptide had the strongest bioactivities, whose IC
Identifiants
pubmed: 38732526
pii: nu16091279
doi: 10.3390/nu16091279
pii:
doi:
Substances chimiques
Glycoside Hydrolase Inhibitors
0
Antioxidants
0
Peptides
0
alpha-Glucosidases
EC 3.2.1.20
Protein Hydrolysates
0
Reactive Oxygen Species
0
Hypoglycemic Agents
0
2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
28752-68-3
Insulin
0
Sulfonic Acids
0
1,1-diphenyl-2-picrylhydrazyl
DFD3H4VGDH
Biphenyl Compounds
0
Picrates
0
Benzothiazoles
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Major Science and Technology Project of the Science and Technology Department of Yunnan Province
ID : 202202AG050009