Expression of CD39 is associated with T cell exhaustion in ovarian cancer and its blockade reverts T cell dysfunction.
Humans
Female
Ovarian Neoplasms
/ immunology
Apyrase
/ metabolism
CD8-Positive T-Lymphocytes
/ immunology
Middle Aged
Ascites
/ immunology
Antigens, CD
/ metabolism
Aged
Programmed Cell Death 1 Receptor
/ metabolism
Receptors, Immunologic
/ metabolism
T Cell Transcription Factor 1
/ metabolism
HLA-DR Antigens
/ metabolism
Adult
T-Cell Exhaustion
High Mobility Group Proteins
Blockade
CD39
CD73
Nanobody
PD-1
TIGIT
malignant ascites
ovarian cancer
Journal
Oncoimmunology
ISSN: 2162-402X
Titre abrégé: Oncoimmunology
Pays: United States
ID NLM: 101570526
Informations de publication
Date de publication:
2024
2024
Historique:
medline:
13
5
2024
pubmed:
13
5
2024
entrez:
13
5
2024
Statut:
epublish
Résumé
Immune exhaustion is a hallmark of ovarian cancer. Using multiparametric flow cytometry, the study aimed to analyze protein expression of novel immunological targets on CD3
Identifiants
pubmed: 38737794
doi: 10.1080/2162402X.2024.2346359
pii: 2346359
pmc: PMC11087076
doi:
Substances chimiques
Apyrase
EC 3.6.1.5
ENTPD1 protein, human
EC 3.6.1.5
TOX protein, human
0
Antigens, CD
0
Programmed Cell Death 1 Receptor
0
TIGIT protein, human
0
Receptors, Immunologic
0
T Cell Transcription Factor 1
0
HLA-DR Antigens
0
High Mobility Group Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2346359Informations de copyright
© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to disclose.