Emergent ribozyme behaviors in oxychlorine brines indicate a unique niche for molecular evolution on Mars.

Mars Evolution, Molecular RNA, Catalytic / metabolism Perchlorates / metabolism Extraterrestrial Environment

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
20 May 2024
Historique:
received: 29 11 2023
accepted: 19 04 2024
medline: 21 5 2024
pubmed: 21 5 2024
entrez: 20 5 2024
Statut: epublish

Résumé

Mars is a particularly attractive candidate among known astronomical objects to potentially host life. Results from space exploration missions have provided insights into Martian geochemistry that indicate oxychlorine species, particularly perchlorate, are ubiquitous features of the Martian geochemical landscape. Perchlorate presents potential obstacles for known forms of life due to its toxicity. However, it can also provide potential benefits, such as producing brines by deliquescence, like those thought to exist on present-day Mars. Here we show perchlorate brines support folding and catalysis of functional RNAs, while inactivating representative protein enzymes. Additionally, we show perchlorate and other oxychlorine species enable ribozyme functions, including homeostasis-like regulatory behavior and ribozyme-catalyzed chlorination of organic molecules. We suggest nucleic acids are uniquely well-suited to hypersaline Martian environments. Furthermore, Martian near- or subsurface oxychlorine brines, and brines found in potential lifeforms, could provide a unique niche for biomolecular evolution.

Identifiants

DOI: 10.1038/s41467-024-48037-2 PMID: 38769315
pubmed: 38769315
doi: 10.1038/s41467-024-48037-2
pii: 10.1038/s41467-024-48037-2
doi:

Substances chimiques

perchlorate 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3863

Subventions

Organisme : National Aeronautics and Space Administration (NASA)
ID : 80NSSC18K1139
Organisme : Research Corporation for Science Advancement (Research Corporation)
ID : Scialog Award 28754

Informations de copyright

© 2024. The Author(s).

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Auteurs

Tanner G Hoog (TG)

Department of Genetics, Cell Biology, and Development, University of Minnesota, 6-160 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA.

Matthew R Pawlak (MR)

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 321 Church Street SE, Minneapolis, MN, 55455, USA.
ORCID: 0000-0003-3834-2164

Nathaniel J Gaut (NJ)

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 321 Church Street SE, Minneapolis, MN, 55455, USA.
ORCID: 0000-0002-7979-0759

Gloria C Baxter (GC)

Department of Genetics, Cell Biology, and Development, University of Minnesota, 6-160 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA.
ORCID: 0009-0007-3156-3622

Thomas A Bethel (TA)

Department of Ecology, Evolution, and Behavior, University of Minnesota, 140 Gortner Laboratory, 1479 Gortner Avenue, St. Paul, MN, 55108, USA.

Katarzyna P Adamala (KP)

Department of Genetics, Cell Biology, and Development, University of Minnesota, 6-160 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA.
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 321 Church Street SE, Minneapolis, MN, 55455, USA.
ORCID: 0000-0003-1066-7207

Aaron E Engelhart (AE)

Department of Genetics, Cell Biology, and Development, University of Minnesota, 6-160 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA. enge0213@umn.edu.
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 321 Church Street SE, Minneapolis, MN, 55455, USA. enge0213@umn.edu.
ORCID: 0000-0002-1849-7700

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiques › Phénomènes astronomiques › Objets astronomiques › Système solaire › Planètes › Mars › Emergent ribozyme behaviors in oxychlorine...
questionsmedicales.fr › Phénomènes biologiques › Évolution biologique › Évolution moléculaire › Emergent ribozyme behaviors in oxychlorine...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › ARN catalytique › Emergent ribozyme behaviors in oxychlorine...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du chlore › Perchlorates › Emergent ribozyme behaviors in oxychlorine...
questionsmedicales.fr › Phénomènes biologiques › Phénomènes écologiques et environnementaux › Environnement extraterrestre › Emergent ribozyme behaviors in oxychlorine...