SA and NHP glucosyltransferase UGT76B1 affects plant defense in both SID2- and NPR1-dependent and independent manner.
Salicylic Acid
/ metabolism
Arabidopsis Proteins
/ genetics
Arabidopsis
/ genetics
Gene Expression Regulation, Plant
Glucosyltransferases
/ genetics
Plant Immunity
/ genetics
Pseudomonas syringae
/ pathogenicity
Pipecolic Acids
/ metabolism
Plant Diseases
/ microbiology
Intramolecular Transferases
/ genetics
FMO1
NPR1
SID2
N-hydroxypipecolic acid
Plant pathogen defense
Salicylic acid
Journal
Plant cell reports
ISSN: 1432-203X
Titre abrégé: Plant Cell Rep
Pays: Germany
ID NLM: 9880970
Informations de publication
Date de publication:
23 May 2024
23 May 2024
Historique:
received:
23
02
2024
accepted:
02
05
2024
medline:
23
5
2024
pubmed:
23
5
2024
entrez:
23
5
2024
Statut:
epublish
Résumé
The small-molecule glucosyltransferase loss-of-function mutant ugt76b1 exhibits both SID2- or NPR1-dependent and independent facets of enhanced plant immunity, whereupon FMO1 is required for the SID2 and NPR1 independence. The small-molecule glucosyltransferase UGT76B1 inactivates salicylic acid (SA), isoleucic acid (ILA), and N-hydroxypipecolic acid (NHP). ugt76b1 loss-of-function plants manifest an enhanced defense status. Thus, we were interested how UGT76B1 genetically integrates in defense pathways and whether all impacts depend on SA and NHP. We study the integration of UGT76B1 by transcriptome analyses of ugt76b1. The comparison of transcripts altered by the loss of UGT76B1 with public transcriptome data reveals both SA-responsive, ISOCHORISMATE SYNTHASE 1/SALICYLIC ACID INDUCTION DEFICIENT 2 (ICS1/SID2)- and NON EXPRESSOR OF PR GENES 1 (NPR1)-dependent, consistent with the role of UGT76B1 in glucosylating SA, and SA-non-responsive, SID2/NPR1-independent genes. We also discovered that UGT76B1 impacts on a group of genes showing non-SA-responsiveness and regulation by infections independent from SID2/NPR1. Enhanced resistance of ugt76b1 against Pseudomonas syringae is partially independent from SID2 and NPR1. In contrast, the ugt76b1-activated resistance is completely dependent on FMO1 encoding the NHP-synthesizing FLAVIN-DEPENDENT MONOOXYGENASE 1). Moreover, FMO1 ranks top among the ugt76b1-induced SID2- and NPR1-independent pathogen responsive genes, suggesting that FMO1 determines the SID2- and NPR1-independent effect of ugt76b1. Furthermore, the genetic study revealed that FMO1, ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1), SID2, and NPR1 are required for the SA-JA crosstalk and senescence development of ugt76b1, indicating that EDS1 and FMO1 have a similar effect like stress-induced SA biosynthesis (SID2) or the key SA signaling regulator NPR1. Thus, UGT76B1 influences both SID2/NPR1-dependent and independent plant immunity, and the SID2/NPR1 independence is relying on FMO1 and its product NHP, another substrate of UGT76B1.
Identifiants
pubmed: 38780624
doi: 10.1007/s00299-024-03228-5
pii: 10.1007/s00299-024-03228-5
doi:
Substances chimiques
Salicylic Acid
O414PZ4LPZ
Arabidopsis Proteins
0
NPR1 protein, Arabidopsis
0
Glucosyltransferases
EC 2.4.1.-
Pipecolic Acids
0
Intramolecular Transferases
EC 5.4.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
149Subventions
Organisme : National Natural Science Foundation of China
ID : 31600993
Organisme : research grants from JiangSu University
ID : 21DJG073
Informations de copyright
© 2024. The Author(s).
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